AB134018

Anti-Myelin Basic Protein antibody

Name: Anti-Myelin Basic Protein antibody (ab134018) | Abcam
Brand: Abcam Limited
SKU: AB134018
Price: 400 USD
Availability: InStock
Rating: 5 (3 reviews)

Lab Essentials
What is this?

(3 Reviews)

(10 Publications)

Chicken Polyclonal Myelin Basic Protein antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human MBP conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody (AB134018)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody (AB134018)

Immunohistochemical analysis of a section of adult mouse brain labelling Myelin Basic Protein (red staining) of white matter tracts adjacent to the hippocampal formation with ab134018 at 1/1000 dilution. Green staining is autofluorescence from green fluorescent protein (GFP) expressed in this transgenic mouse.

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MBP conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P02686

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2000", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, the concentrations of the eluate adjusted to 100 µg/ml, and the preparation was filter-sterilized.

Storage buffer

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle|Store undiluted

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.

Biological function summary

MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.

Pathways

MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.

MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

See full target information MBP

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Signal transduction and targeted therapy 10:295 PubMed40931022

2025

Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hye Yeong Lee,Jung Moo Lee,Hye-Lan Lee,Jiyeon Park,Heeyoung An,Eun Kyung Park,Sae Yeon Hwang,Sol Lip Yoon,Gwang Yong Hwang,Keung Nyun Kim,Min-Ho Nam,Seung Eun Lee,Hyunji Kang,Joungha Won,Bo Ko Jang,Elijah Hwejin Lee,SunYeong Choi,Mingu Gordon Park,Sang Wook Kim,Ki Duk Park,SeungHwan Lee,C Justin Lee,Yoon Ha

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22:e00547 PubMed39955176

2025

Effects of chemogenetic virus injection and clozapine administration in spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hyeon Kim,Sae Yeon Hwang,Hye-Lan Lee,Sol Lip Yoon,Yoon Ha,Hye Yeong Lee,Seungjun Ryu

Diagnostics (Basel, Switzerland) 13: PubMed37174921

2023

Acquisition and Analysis of Excised Neocortex from Pediatric Patients with Focal Cortical Dysplasia Using Mesoscale Diffusion MRI.

Applications

Unspecified application

Species

Unspecified reactive species

Chandler Fountain,Harmanvir Ghuman,Michael Paldino,Mandeep Tamber,Ashok Panigrahy,Michel Modo

iScience 26:106340 PubMed37009213

2023

Global sphingosine-1-phosphate receptor 2 deficiency attenuates neuroinflammation and ischemic-reperfusion injury after neonatal stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Yumi Fukuzaki,Joel Faustino,Matthieu Lecuyer,Aditya Rayasam,Zinaida S Vexler

International journal of molecular sciences 22: PubMed33810144

2021

Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher Kapitza,Rittika Chunder,Anja Scheller,Katherine S Given,Wendy B Macklin,Michael Enders,Stefanie Kuerten,Winfried L Neuhuber,Jürgen Wörl

FASEB journal : official publication of the Federa 34:8833-8842 PubMed32929779

2020

Conditional Lpar1 gene targeting identifies cell types mediating neuropathic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Richard R Rivera,Mu-En Lin,Emily C Bornhop,Jerold Chun

Neuron 104:960-971.e7 PubMed31630908

2019

TREK-1 and TRAAK Are Principal K Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.

Applications

Unspecified application

Species

Unspecified reactive species

Hirosato Kanda,Jennifer Ling,Sotatsu Tonomura,Koichi Noguchi,Sadis Matalon,Jianguo G Gu

Neurochemical research 44:2170-2181 PubMed31420834

2019

Elevated Neuroglobin Lessens Neuroinflammation and Alleviates Neurobehavioral Deficits Induced by Acute Inhalation of Combustion Smoke in the Mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Murat F Gorgun,Ming Zhuo,Kelly T Dineley,Ella W Englander

Nature chemical biology 14:22-28 PubMed29131145

2017

Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.

Applications

ICC/IF

Species

Mouse

Brittney A Beyer,Mingliang Fang,Benjamin Sadrian,J Rafael Montenegro-Burke,Warren C Plaisted,Bernard P C Kok,Enrique Saez,Toru Kondo,Gary Siuzdak,Luke L Lairson

Human brain mapping 37:780-95 PubMed26611565

2015

Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Michel Modo,T Kevin Hitchens,Jessie R Liu,R Mark Richardson

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Myelin Basic Protein antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody (AB134018)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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