AB31851

Anti-Myelin Protein Zero antibody

Name: Anti-Myelin Protein Zero antibody. Rabbit polyclonal (ab31851) | Abcam
Brand: Abcam Limited
SKU: AB31851
Rating: 4 (14 reviews)

(14 Reviews)

(64 Publications)

Rabbit Polyclonal Myelin Protein Zero antibody. Suitable for WB and reacts with Mouse samples. Cited in 64 publications.

View Alternative Names

P0, Myelin protein P0, Myelin peripheral protein, Myelin protein zero, MPP

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Project

Western blot - Anti-Myelin Protein Zero antibody (AB31851)

We also see a similar banding pattern in Rat Sciatic Nerve lysate although the band is more smeared then observed in the Western Blot shown here. We believe the smearing is caused by glycosylation of the target protein.

All lanes:

Western blot - Anti-Myelin Protein Zero antibody (ab31851) at 1 µg/mL

All lanes:

Mouse Sciatic Nerve Whole Tissue Lysate at 20 µg

Secondary

All lanes:

IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution

Predicted band size: 28 kDa

Observed band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myelin protein zero sometimes called MPZ or P0 is a structural protein in the peripheral nervous system. It has a molecular mass of approximately 30 kDa. Myelin protein zero is mostly found in Schwann cells where it plays an important role in the formation of the myelin sheath. This protein facilitates the adhesion between layers of the myelin membrane contributing to the compact structure of the myelin sheath surrounding nerve fibers.

Biological function summary

Several functions of nerve insulating layers involve myelin protein zero. It forms part of the myelin sheath critical for effective nerve signal transmission. The protein is associated with the Ig superfamily and interacts with other myelin components to maintain integrity and functionality. Myelin protein zero also affects the clustering of specific proteins and lipids within the myelin sheath making it an important component in maintaining the stability and function of peripheral nerves.

Pathways

Several important signal transmission processes involve the interactions of myelin protein zero. It is involved in the myelination pathway which is essential for insulating nerve fibers and speeding up action potential propagation. The protein is closely related to connexin 32 in this pathway another protein involved in maintaining the proper function of myelinated neurons. This coordination helps ensure efficient communication in the peripheral nervous system.

Several neurological conditions link to abnormalities in myelin protein zero. Mutations in the gene encoding this protein can lead to Charcot-Marie-Tooth disease type 1B a hereditary neuropathy characterized by muscle weakness and sensory loss. Alterations in myelin protein zero are also associated with Dejerine-Sottas syndrome a severe neuropathy involving early-onset muscle weakness. The protein's relation to other myelin proteins like PMP22 often signifies its role in the molecular mechanisms underlying these demyelinating disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.

See full target information Mpz

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Publications (64)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40650234

2025

Limited Myelination Capacity in Human Schwann Cells in Experimental Models in Comparison to Rodent and Porcine Schwann Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tak-Ho Chu,Rajiv Midha

Scientific reports 15:15581 PubMed40320399

2025

Predegenerating donor nerve for grafting using focused ultrasound neurotomy.

Applications

Unspecified application

Species

Unspecified reactive species

Tak-Ho Chu,Nicolas Lasaleta,Siyun Li,Amanda McConnachie,Leonardo Molina,Saud Alzahrani,Laura Curiel,Samuel Pichardo,Rajiv Midha

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2308965 PubMed39680476

2024

Schwann Cell-Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa Gambarotto,Loris Russo,Silvia Bresolin,Luca Persano,Rachele D'Amore,Giulia Ronchi,Federica Zen,Luisa Muratori,Alice Cani,Samuele Negro,Aram Megighian,Sonia Calabrò,Paola Braghetta,Dario Bizzotto,Matilde Cescon

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 37:160-163 PubMed39359129

2024

Schwannosis in the brain of a neonatal calf.

Applications

Unspecified application

Species

Unspecified reactive species

Diana Bochynska,Ann Sharpe,Brian Toland,Elena Alina Demeter

International journal of molecular sciences 25: PubMed39063088

2024

Cilostazol Ameliorates Motor Dysfunction and Schwann Cell Impairment in Streptozotocin-Induced Diabetic Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Lin-Li Chang,Yu-Ming Wu,Hung-Chen Wang,Kuang-Yi Tseng,Yi-Hsuan Wang,Yen-Mou Lu,Kuang-I Cheng

Biomolecules 14: PubMed38672423

2024

The Influence of Lysosomal Stress on Dental Pulp Stem Cell-Derived Schwann Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Karen Libberecht,Nathalie Dirkx,Tim Vangansewinkel,Wendy Vandendries,Ivo Lambrichts,Esther Wolfs

Molecular therapy : the journal of the American Society of Gene Therapy 32:1407-1424 PubMed38429927

2024

Gene therapy approaches for obesity-induced adipose neuropathy: Device-targeted AAV-mediated neurotrophic factor delivery to adipocytes in subcutaneous adipose.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Blaszkiewicz,Tianyi Tao,Kofi Mensah-Arhin,Jake W Willows,Rhiannon Bates,Wei Huang,Lei Cao,Rosemary L Smith,Kristy L Townsend

Neural regeneration research 19:1575-1583 PubMed38051902

2023

Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Hu,Xinpeng Dun,Lolita Singh,Matthew C Banton

Frontiers in immunology 14:1229414 PubMed37675123

2023

Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal.

Applications

Unspecified application

Species

Unspecified reactive species

Makoto Hosoya,Tsubasa Kitama,Marie N Shimanuki,Takanori Nishiyama,Naoki Oishi,Hideyuki Okano,Hiroyuki Ozawa

Aging cell 22:e13784 PubMed36798047

2023

Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Jake W Willows,Morganne Robinson,Zahra Alshahal,Samantha K Morrison,Gargi Mishra,Harrison Cyr,Magdalena Blaszkiewicz,Gilian Gunsch,Sabrina DiPietro,Emma Paradie,Benjamin Tero,Anne Harrington,Larisa Ryzhova,Lucy Liaw,Peter C Reifsnyder,David E Harrison,Kristy L Townsend

View all publications

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Product promise

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Anti-Myelin Protein Zero antibody

Western blot - Anti-Myelin Protein Zero antibody (AB31851)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (64)

Product promise