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AB63860

Anti-Myeloid Precursor Cells antibody [ER-MP58]

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(2 Publications)

Rat Monoclonal Myeloid Precursor Cells antibody. Suitable for Flow Cyt, IHC-Fr, IP, ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Myeloid Precursor Cells protein.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

ER-MP58

Isotype

IgG2a

Carrier free

No

Reacts with

Mouse

Applications

IHC-Fr, Flow Cyt, IP, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 10μl of the suggested working dilution to label 10<sup>6</sup> cells in 100μl</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/25 - 1/100", "IHCFr-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myeloid precursor cells also known as myeloid progenitors are important cells in hematopoiesis the process through which blood cells form. These cells have a role in early stages of differentiation that lead to various myeloid lineages like granulocytes monocytes erythrocytes and platelets. Myeloid precursors are found primarily in the bone marrow which is their site of origin and where they proliferate and differentiate. The molecular mass of these cells is not typically defined because they represent a cell population rather than a single molecular entity.
Biological function summary

Myeloid precursor cells are involved in generating the immune system's innate components. They initiate the formation of cells that function in first-line defense against pathogens. While myeloid precursors are not part of a specific protein complex they are integrally related to their progeny which perform various biological roles ranging from phagocytosis and antigen presentation to oxygen transport. These cells carry important markers and signaling pathways that guide their differentiation and function.

Pathways

Myeloid precursor cells participate in critical signaling networks that regulate hematopoiesis such as the JAK-STAT and MAPK pathways. These pathways influence cell survival proliferation and differentiation decisions. Myeloid precursors interact with key proteins such as colony-stimulating factors (CSFs) and interleukins influencing their trajectory into specific myeloid cells. Understanding these pathways aids in deciphering the complex patterns of lineage commitment and differentiation.

Myeloid precursor cells have significant implications in conditions like leukemia and myelodysplastic syndromes. These cells may undergo malignant transformations leading to uncontrolled proliferation as seen in acute myeloid leukemia (AML). Aberrant signaling through pathways involving proteins such as FLT3 and RUNX1 can result in these conditions. Research into how myeloid precursors contribute to these disorders provides insights into potential therapeutic targets for treating hematological malignancies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Myeloid Precursor Cells
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Blood 118:5255-66 PubMed21937699

2011

Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia.

Applications

Flow Cyt

Species

Mouse

Manjula Karpurapu,Xuerong Wang,Jing Deng,Hyesuk Park,Lei Xiao,Ruxana T Sadikot,Randall S Frey,Ulrich A Maus,Gye Young Park,Edward W Scott,John W Christman

The Journal of biological chemistry 284:29087-96 PubMed19720836

2009

Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone.

Applications

IHC-P

Species

Mouse

Xin Lu,Yibin Kang
View all publications
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Product promise

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