Mouse Monoclonal MYH6 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 9 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MYH6.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img36887.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926)")
![Western blot - Anti-MYH6 antibody [3-48 G5C7] (AB207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--western-blot-img30606.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-MYH6 antibody [3-48 G5C7] (AB207926)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img125200.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img53275.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (AB207926)")
Publications
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- Scientific reports 13:222012023A non-invasive mouse model that recapitulates disuse-induced muscle atrophy in immobilized patients.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun-Chang Wu,Hsiang-Wen Lin,Po-Chen Chu,Chia-Ing Li,Hsiang-Han Kao,Chih-Hsueh Lin,Yu-Jung ChengPubMed 38097709
- Heliyon 8:e120992022Qingda granule prevents obesity-induced hypertension and cardiac dysfunction by inhibiting adverse Akt signaling activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQian Gao,En Ma,Jinxiao Chen,Qiqin Zhao,Jia He,Jun Peng,Weidong Zhu,Dan-Ni Ren,Da WoPubMed 36578425
- Scientific reports 12:43372022Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLuqia Hou,Mohit Kumar,Priti Anand,Yinhong Chen,Nesrine El-Bizri,Chad J Pickens,W Michael Seganish,Sakthivel Sadayappan,Gayathri SwaminathPubMed 35288601
- Molecular medicine reports 24:2021Interactions between the ERK1/2 signaling pathway and PCAF play a key role in PE‑induced cardiomyocyte hypertrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQian Mao,Shuqi Wu,Chang Peng,Bohui Peng,Xiaomei Luo,Lixin Huang,Huanting ZhangPubMed 34278478
- ACS infectious diseases 7:1483-15022021The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNathanael D Reynolds,Nathalie M Aceves,Jinny L Liu,Jaimee R Compton,Dagmar H Leary,Brendan T Freitas,Scott D Pegan,Katarina Z Doctor,Fred Y Wu,Xin Hu,Patricia M LeglerPubMed 34019767
- Molecular medicine reports 22:1783-17922020Calcium inhibitor inhibits high glucose‑induced hypertrophy of H9C2 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaohong Xu et. al.PubMed 32705176
- Circulation research 120:1403-14132017Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSophie Dal-Pra et. al.PubMed 28209718
- Molecular medicine reports 14:2860-62016MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Liu et. al.PubMed 27485101
- Cellular physiology and biochemistry : internation 27:121-82011Transgenic overexpression of heart-specific adenine nucleotide translocase 1 positively affects contractile function in cardiomyocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesInga Vogelpohl et. al.PubMed 21325829
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Native Full Length Protein corresponding to Human MYH6. Database link P13533
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Expected | Tested |
| Rat | Expected | Tested |
| Cow | Predicted | Predicted |
| Dog | Predicted | Predicted |
| Pig | Predicted | Predicted |
| Rabbit | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/2000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit, Cow, Dog, Pig | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1 µg/mL | Notes - |
Species Rat | Dilution info 1 µg/mL | Notes - |
Species Human | Dilution info 1 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit, Cow, Dog, Pig | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Alternative names
MYHCA, MYH6, Myosin-6, Myosin heavy chain 6, MyHC-alpha
Recommended products
Mouse Monoclonal MYH6 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 9 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MYH6.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Native Full Length Protein corresponding to Human MYH6. Database link P13533
- Clone number
- 3-48 G5C7
- Purification technique
- Affinity purification Protein G
- Specificity
This antibody recognizes alpha and beta type MYH6 fragments (LMM) of cardiac myosin heavy chains. It also reacts with LMM fragments of cardiac myosin and beta heavy chain of slow human skeletal muscle. The antibody does not crossreact with human myosin light chains Specific for: human, rat and mouse; other species not tested but it is expected to also recognize and heavy chain from canine, bovine and rabbit cardiac tissues.
- Light chain type
- kappa
- Concentration
- Purification notes
Lyophilized protein G purified in PBS pH7.4 (Full IgG).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Molecular weight if IgG: according to SDS-PAGE under mercaptoethanol (reduced conditions) 153.8 kd. Heavy chain: 49.7 kd light chain: 27.2 kd.
Molecular weight of F(ab')2: according to SDS-PAGE under mercaptoethanol (reduced conditions) 116 kd. Heavy chain: 30.8 kd light chain: 27.2 kd
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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4 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img36887.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded mouse heart tissue labeling MYH6 with ab207926 at 1 μg/ml.
![Western blot - Anti-MYH6 antibody [3-48 G5C7] (ab207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--western-blot-img30606.jpg "Western blot - Anti-MYH6 antibody [3-48 G5C7] (ab207926)")
Western blot - Anti-MYH6 antibody [3-48 G5C7] (ab207926)
All lanes: Western blot - Anti-MYH6 antibody [3-48 G5C7] (ab207926) at 1/2000 dilution
Lane 1: Human fetal heart tissue lysate at 20 µg
Lane 2: Human fetal heart tissue lysate at 5 µg
Lane 3: Human adult heart tissue lysate at 20 µg
Lane 4: Mouse heart tissue lysate at 20 µg
Lane 5: Rat heart tissue lysate at 20 µg
Lane 6: Human skeletal muscle tissue lysate at 20 µg
Lane 7: Mouse skeletal muscle tissue lysate at 20 µg
Lane 8: Rat skeletal muscle tissue lysate at 20 µg
Lane 9: Human liver tissue lysate at 20 µg
Predicted band size: 224 kDa
Observed band size: 220 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img125200.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human heart tissue labeling MYH6 with ab207926 at 1 μg/ml.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926), expandable thumbnail](https://content.abcam.com/products/images/myh6-antibody-3-48-g5c7-ab207926--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img53275.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYH6 antibody [3-48 G5C7] (ab207926)
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded rat heart tissue labeling MYH6 with ab207926 at 1 μg/ml.
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