AB58699

Anti-MYO10 antibody

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(2 Publications)

Rabbit Polyclonal MYO10 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MYO10.

View Alternative Names

KIAA0799, MYO10, Unconventional myosin-X, Unconventional myosin-10

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Applications

ELISA, WB

applications

Immunogen

Synthetic Peptide within Human MYO10. The exact immunogen used to generate this antibody is proprietary information.

Q9HD67

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mechanically MYO10 also known as Myosin-X is an unconventional myosin motor protein with a molecular mass of approximately 237 kDa. This protein has a significant presence in specialized cellular structures such as filopodia and neuron growth cones. It functions as a motor that transports cellular cargo along actin filaments playing an important role in cellular movement and organization. Expression of MYO10 occurs in various tissues but it is notably abundant in the brain and testis.

Biological function summary

MYO10 facilitates several cellular processes by mediating actin-based transport and cellular structure dynamics. It forms part of a complex network interacting with actin filaments influencing the dynamics of cell protrusions such as filopodia. These processes are essential for cell migration development and intracellular transport where MYO10 acts as an anchor enabling cells to respond to external stimuli and migrate accordingly.

Pathways

MYO10 interacts with various molecular networks influencing critical signaling cascades. It plays a significant role in the Wnt signaling pathway by interacting with Dishevelled (Dvl) proteins impacting cell polarization and movement. Additionally MYO10 is involved in integrin signaling facilitating the formation of adhesive contacts necessary for cell movement linking proteins such as talin and integrins into the pathway for integrative structural and signal modulation.

MYO10 has connections with certain pathologies particularly cancer and neurological disorders. Abnormal expression or mutation of MYO10 could contribute to cancer progression by disrupting normal cell migration and adhesion thereby aiding metastasis. In neurological disorders MYO10 has associations with proteins such as Reelin and its dysregulation could contribute to impaired neuronal migration or connectivity elucidating some neurological pathologies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed : 27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.. Isoform Headless. Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).

See full target information MYO10

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 21:285 PubMed38066646

2023

Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Yang,Chun Zhao,Beili Chen,Xiaoning Yu,Yuxi Zhou,Danyu Ni,Xiaolan Zhang,Junqiang Zhang,Xiufeng Ling,Zhiguo Zhang,Ran Huo

Scientific reports 6:25105 PubMed27121283

2016

A novel type 2 diabetes risk allele increases the promoter activity of the muscle-specific small ankyrin 1 gene.

Applications

Unspecified application

Species

Unspecified reactive species

Rengna Yan,Shanshan Lai,Yang Yang,Hongfei Shi,Zhenming Cai,Vincenzo Sorrentino,Hong Du,Huimei Chen

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-MYO10 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise