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AB81690

Anti-MYO18A antibody

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(1 Publication)

Rabbit Polyclonal MYO18A antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MYO18A aa 2000 to C-terminus.

View Alternative Names

CD245, KIAA0216, MYSPDZ, TIAF1, MYO18A, Unconventional myosin-XVIIIa, Molecule associated with JAK3 N-terminus, Myosin containing a PDZ domain, Surfactant protein receptor SP-R210, MAJN, SP-R210

1 Images
Immunoprecipitation - Anti-MYO18A antibody (AB81690)
  • IP

Unknown

Immunoprecipitation - Anti-MYO18A antibody (AB81690)

Detection of human MYO18A by Western Blot of Immunoprecipitates.
Samples : RIPA whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.
ab81690 used for IP at 3 μg/mg lysate (lane 2).
MYO18A was also immunoprecipitated by rabbit anti MYO18A (ab81689), which recognizes an upstream epitope (lane 1).
Lane 3 represents the control IgG.
For blotting immunoprecipitates, ab81689 was used at 1 μg/ml.
Detection : by Chemiluminescence with an exposure time of 1 second.

All lanes:

Immunoprecipitation - Anti-MYO18A antibody (ab81690)

Predicted band size: 233 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human MYO18A aa 2000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92614

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab81690 was affinity purified using an epitope specific to MYO18A immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MYO18A protein also known as Myosin XVIIIA is a non-conventional myosin with a molecular mass of approximately 200 kDa. This protein is involved in actin-based cellular functions and motor activities. MYO18A displays broad expression in various tissues notably in muscle and neural tissues functioning as an essential element of the cytoskeleton. It shows properties that connect it to both structural and regulatory roles within cells.
Biological function summary

Within cellular contexts MYO18A participates in cytoskeletal organization affecting cell shape and movement. This protein functions as a part of microfilament structures and associates with other proteins to form complexes contributing to cellular dynamics regulation. It modulates actin filament stability and participates in cellular protrusion and migration impacting locomotion and signaling pathways.

Pathways

MYO18A integrates into cytoskeletal and signaling networks linking it with pathways such as the Rho-signaling and MAPK pathways. It interacts with proteins like actin and possibly collaborates with Rho-associated coiled-coil-containing protein kinases (ROCK) to mediate some of its functions. MYO18A-related pathways are important for cellular dynamics and overall homeostasis influencing tissue development and repair.

Abnormalities in MYO18A have been linked to cancer and neuromuscular disorders. In oncology its expression changes may associate with tumor progression potentially interacting with other proteins like SRC kinase that affect cell adhesion and proliferation. In neuromuscular contexts MYO18A mutations or dysregulation can relate to disorders impacting muscle function and integrity aligning with proteins like dystrophin involved in muscle structure and signaling.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed : 19837035, PubMed : 23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed : 18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed : 25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed : 16087679, PubMed : 21123169). Strongly enhances natural killer cell cytotoxicity (PubMed : 27467939).
See full target information MYO18A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC complementary medicine and therapies 21:259 PubMed34627204

2021

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.

Applications

Unspecified application

Species

Unspecified reactive species

Hei-Jen Huang,Jie-Ling Chen,Jian-Fu Liao,Yu-Hsin Chen,Min-Wei Chieu,Ya-Yun Ke,Chih-Chieh Hsu,Ying-Chieh Tsai,Hsiu Mei Hsieh-Li
View all publications
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