Anti-MYO5B antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MYO5B also known as myosin-Vb is a motor protein that plays a significant role in cellular transport. It exhibits a molecular mass of approximately 215 kDa. MYO5B interacts with actin filaments conducting transport of cargo through the cell via ATP hydrolysis. It is chiefly found in epithelial cells such as those lining the intestines and kidneys. This protein localizes to various intracellular compartments including the plasma membrane and endosomal compartments facilitating organelle and protein transport critical for maintaining cellular function.

Biological function summary

The mechanical movements generated by MYO5B are essential for intracellular trafficking processes. It serves as a component of the transport machinery involving membrane trafficking ensuring the proper distribution of cellular materials. As part of a molecular complex MYO5B works in conjunction with Rab GTPases to regulate vesicle movement. This coordination helps maintain the polarity and integrity of epithelial cells which are important for nutrient absorption and secretion in tissues.

Pathways

MYO5B is intimately involved in the regulation of the endocytic recycling pathway. It plays a pivotal role in the recycling of receptors and lipids back to the plasma membrane. The protein interfaces with key elements such as RAB11A which is important for the recycling pathway. MYO5B’s function in this pathway is integral for maintaining epithelial cell dynamics and tissue homeostasis ensuring correct receptor and nutrient transporter localization in the cellular membrane.

Associated diseases and disorders

Dysfunctional MYO5B is implicated in microvillus inclusion disease (MVID) a disorder that disrupts nutrient absorption in the intestines. This protein forms links with RAB11A and promotes disruptions when mutated leading to the symptoms observed in MVID. Additionally MYO5B mutations have associations with cholestasis a condition where bile cannot flow from the liver to the duodenum. The relationship with other proteins like syntaxin 3 further complicates cholestasis pathophysiology highlighting MYO5B’s broad impact in human diseases.