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AB246859

Anti-MYOM2 antibody

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Rabbit Polyclonal MYOM2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYOM2 aa 1-200.

View Alternative Names

Myomesin-2, 165 kDa connectin-associated protein, 165 kDa titin-associated protein, M-protein, Myomesin family member 2, MYOM2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-MYOM2 antibody (AB246859)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MYOM2 antibody (AB246859)

PFA-fixed, Triton X-100 permeabilized HEK-293 (human epithelial cell line from embryonic kidney) cells stained for MYOM2 (green) using ab246859 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB246859)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB246859)

Paraffin-embedded human heart muscle tissue stained for MYOM2 using ab246859 at 1/20 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB246859)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM2 antibody (AB246859)

Paraffin-embedded human prostate tissue stained for MYOM2 using ab246859 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MYOM2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P54296

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MYOM2 also known as myomesin-2 is a protein involved in muscle structure and function. It has a molecular mass of roughly 166 kDa. This protein is predominantly expressed in cardiac and skeletal muscle tissues. MYOM2 plays an important mechanical role by contributing to the M-line of the sarcomere which is essential for muscle elasticity and contractility acting as a link between myosin thick filaments and other structural proteins within the muscle cell.
Biological function summary

MYOM2 integrates into the sarcomeric M-band complex. This complex is important for maintaining the structural integrity of myofibrils. MYOM2 stabilizes interactions between the thick filament protein myosin and other M-band proteins such as myomesin-1 and myomesin-3. This stabilization supports muscle contraction processes and overall muscle fiber architecture adapting muscle cells to mechanical stress.

Pathways

MYOM2 is involved in muscle contraction and structural organization pathways. Specifically it plays a part in the myofibril assembly pathway where it collaborates with other proteins like titin and myosin binding protein C to ensure proper sarcomere assembly. These interactions help maintain the functional properties of muscle tissues contributing to force generation and transmission across muscle cells.

MYOM2 has associations with muscle-related diseases particularly hypertrophic cardiomyopathy (HCM). This disease impacts cardiac muscle and is linked with mutations or variations in MYOM2 and related proteins such as myomesin-1 and titin. Additionally MYOM2 may contribute to myofibrillar myopathy a disorder characterized by disorganization of myofibrils within muscle cells where changes in its structure can disrupt muscle function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
See full target information MYOM2
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