Anti-Myoneurin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Myoneurin also known as MYNN is a protein involved in transcription regulation. This protein has a molecular mass of approximately 78 kDa. It shows expression in a variety of tissues but is particularly enriched in the skeletal muscle and central nervous system. Myoneurin's role stems from its capacity to interact with DNA and influence the transcription of specific genes which makes it significant in cellular and developmental processes.

Biological function summary

Myoneurin contributes to regulating gene expression. It acts as a part of multi-protein complexes required in nucleosome remodeling and transcription activation. Through these complexes Myoneurin alters chromatin structure facilitating the accessibility of transcription factors to DNA. This function is important for the fine-tuning of gene expression that affects cell cycle progression and differentiation especially within muscular and neural contexts.

Pathways

Several processes partly depend on Myoneurin. Notably it involves the muscle cell differentiation pathway and neural development. It interacts with proteins such as MEF2 a transcription factor that modulates gene expression in muscle cells and CREB implicated in long-term memory formation both participating in gene regulatory networks coordinated by Myoneurin. These interactions suggest its role in gene pathways that govern tissue-specific functional outcomes.

Associated diseases and disorders

Myoneurin is linked to certain muscular and neurodegenerative conditions. Alterations or deficiencies in Myoneurin expression relate to muscle atrophy and have been studied in contexts like muscular dystrophies. Additionally Myoneurin's interaction with proteins like SMN linked with spinal muscular atrophy highlights its potential involvement in neuromuscular disorders. Understanding these connections could advance therapeutic strategies for these diseases.