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AB121125

Anti-Myosin 18B antibody

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(1 Publication)

Rabbit Polyclonal MY18B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Unconventional myosin-XVIIIb aa 2400 to C-terminus.

View Alternative Names

Unconventional myosin-XVIIIb, MYO18B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myosin 18B antibody (AB121125)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myosin 18B antibody (AB121125)

ab121125 at 1/10 dilution staining Myosin 18B in Paraffin-emebedded Human kidney tissue by Immunohistochemistry. Note : moderate cytoplasmic positivity in renal tubules.

Immunocytochemistry/ Immunofluorescence - Anti-Myosin 18B antibody (AB121125)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Myosin 18B antibody (AB121125)

Immunofluorescent staining of human cell line A431 using ab121125 at a concentration of 4 µg/ml. Note : shows positivity in nucleus but not nucleoli & cytoplasm.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Unconventional myosin-XVIIIb aa 2400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IUG5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myosin 18B also known as MYO18B is a molecular motor protein involved in cellular movement and structure. This protein has a mass of approximately 229 kDa. It mainly facilitates actin binding and muscular contraction. Myosin 18B is expressed in skeletal muscle and cardiac muscle tissues and shows a presence in some non-muscle tissues suggesting diverse functions beyond muscle contraction.
Biological function summary

Myosin 18B plays an important role in maintaining the integrity of cellular and muscular structures. It is part of a complex that interacts with other cytoskeletal proteins contributing to cellular architecture. By localizing to the cytoskeleton Myosin 18B helps structurally support cells and tissues ensuring proper cellular organization and stability.

Pathways

Myosin 18B interacts with actin filaments within the cells which are pivotal in the regulation of cell shape and contraction. It participates in the Rho signaling pathway which controls actin cytoskeleton dynamics influencing cell adhesion and migration. Myosin 18B acts together with proteins like MYO9B in these pathways coordinating cellular responses to environmental and developmental signals.

Myosin 18B has a connection with certain muscular dystrophies and cancers. Mutations in the MYO18B gene have been linked to hypertrophic cardiomyopathy a disease characterized by thickening of the heart muscle. The protein's role in cancer is related to its interaction with the tumor suppressor protein APC indicating possible implications in tumor progression and metastasis. These associations with disease highlight the significance of further research into Myosin 18B's functions and mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
See full target information Unconventional myosin-XVIIIb
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Current biology : CB 29:81-92.e5 PubMed30581023

2018

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.

Applications

Unspecified application

Species

Unspecified reactive species

Yaming Jiu,Reena Kumari,Aidan M Fenix,Niccole Schaible,Xiaonan Liu,Markku Varjosalo,Ramaswamy Krishnan,Dylan T Burnette,Pekka Lappalainen
View all publications
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Product promise

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