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AB236511

Anti-Myostatin Propeptide antibody [OTI6A7]

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(4 Publications)

Mouse Monoclonal GDF8 / Myostatin antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MSTN aa 1-300.

View Alternative Names

GDF8, MSTN, Growth/differentiation factor 8, GDF-8, Myostatin

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI6A7

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MSTN aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

O14793

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Alternative Products

Primary Antibodies

AB134682

Anti-Myostatin Propeptide antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myostatin Propeptide antibody (AB134682)

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Complementary Products

Assay Kits

AB267656

Human Myostatin ELISA kit

Sandwich ELISA - Human Myostatin ELISA kit (AB267656)

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Primary Antibodies

AB124721

Anti-GDF11 + GDF8/Myostatin antibody [EPR4567(2)]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GDF11 + GDF8/Myostatin antibody [EPR4567(2)] (AB124721)

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Primary Antibodies

AB168372

Anti-Fbx32 antibody [EPR9148(2)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Fbx32 antibody [EPR9148(2)] (AB168372)

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Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

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Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Goat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Clone OTI6A7 (formerly 6A7).
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myostatin Propeptide also known as myostatin peptide or anti-myostatin acts as an important regulator by binding to its parent myostatin protein. This binding prevents the myostatin protein from interacting with its receptors modulating its activity. Myostatin Propeptide has a molecular weight of approximately 40 kDa. It is primarily expressed in skeletal muscle tissue reflecting its role in muscle biology. Myostatin Propeptide's interaction with myostatin provides an essential control mechanism within muscle development.
Biological function summary

Myostatin Propeptide inhibits the function of myostatin a member of the Transforming Growth Factor-beta (TGF-beta) superfamily. Myostatin typically suppresses muscle growth so the propeptide acts as a decoy permitting muscle hypertrophy by blocking myostatin activity. This regulation is important in maintaining muscle mass and function. The propeptide does not usually function as part of a large complex instead acting directly to neutralize myostatin in the extracellular environment.

Pathways

Myostatin and its propeptide play major roles in the TGF-beta signaling pathway. This pathway is significant in regulating cell growth and differentiation in various tissues including muscle. Myostatin Propeptide's inhibition of myostatin leads to increased activation of the Akt/mTOR pathway promoting protein synthesis and muscle growth. It also interacts with related proteins such as follistatin another myostatin inhibitor which enhances the modulation of muscle mass through similar mechanisms.

Myostatin Propeptide has relevance in conditions related to muscle wasting such as muscular dystrophy and cachexia. By antagonizing myostatin the propeptide can potentially alleviate muscle degeneration in these conditions. Its role is also significant in sarcopenia an age-related loss of muscle mass providing a target for therapeutic approaches. In these disorders the propeptide's action may involve interactions with proteins like activin receptor type IIB which is involved in the signaling pathways mediated by myostatin.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts specifically as a negative regulator of skeletal muscle growth.
See full target information MSTN
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 15:1418485 PubMed39239655

2024

Astragalus membranaceus and its monomers treat peritoneal fibrosis and related muscle atrophy through the AR/TGF-β1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Li Sheng,Jinyi Sun,Liyan Huang,Manshu Yu,Xiaohui Meng,Yun Shan,Huibo Dai,Funing Wang,Jun Shi,Meixiao Sheng

Journal of cachexia, sarcopenia and muscle 14:2289-2300 PubMed37582652

2023

A novel splice variant of the human MSTN gene encodes a myostatin-specific myostatin inhibitor.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuhiro Maeta,Manal Farea,Hisahide Nishio,Masafumi Matsuo

eLife 12: PubMed37010266

2023

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Xinqi Lou,Yingjie Zha,Yinyin Qin,Jun Zha,Lei Hong,Zhanli Xie,Shudi Yang,Chen Wang,Jianzhong An,Zhenhao Zhang,Shigang Qiao

International journal of molecular sciences 23: PubMed35563408

2022

An Antisense Oligonucleotide against a Splicing Enhancer Sequence within Exon 1 of the Gene Inhibits Pre-mRNA Maturation to Act as a Novel Myostatin Inhibitor.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuhiro Maeta,Manal Farea,Hisahide Nishio,Masafumi Matsuo
View all publications
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Product promise

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