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AB241982

Anti-Myotrophin antibody

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(1 Publication)

Rabbit Polyclonal Myotrophin antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MTPN aa 50 to C-terminus.

View Alternative Names

Myotrophin, Protein V-1, MTPN

1 Images
Western blot - Anti-Myotrophin antibody (AB241982)
  • WB

Supplier Data

Western blot - Anti-Myotrophin antibody (AB241982)

Lysates prepared using NETN lysis buffer.

Lane 1:

Western blot - Anti-Myotrophin antibody (ab241982) at 0.1 µg/mL

Lanes 2 - 5:

Western blot - Anti-Myotrophin antibody (ab241982) at 0.1 µg

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 15 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 15 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 15 µg

Lane 4:

TCMK-1 (mouse kidney epithelial cell line) whole cell lysate at 15 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 15 µg

Predicted band size: 13 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MTPN aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P58546

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antibody was affinity purified using an epitope specific to Myotrophin immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myotrophin also known as V-1 is a protein that facilitates numerous cellular activities. This protein has a molecular weight of approximately 12 kDa and is expressed in several tissues including cardiac and skeletal muscles. It shows high presence in the brain and heart suggesting significant roles in these organs. Myotrophin's ability to modulate multiple cellular functions makes it a target of interest in scientific research focused on cardiac function and neurobiology.
Biological function summary

This protein plays a role in modulating cardiac muscle cell hypertrophy directly affecting heart muscle growth. Myotrophin participates in forming a complex with other proteins such as calpactin which influences actin filament dynamics. This interaction is essential for cellular structural maintenance and function. Additionally myotrophin acts as a transcription factor modulator impacting the expression of genes associated with cellular growth and differentiation.

Pathways

Myotrophin integrates into signaling networks like the NF-kB and MAPK pathways. These pathways are critical for cellular responses to stress and inflammation. Myotrophin interacts with proteins such as p65 (a subunit of NF-kB) to modulate transcriptional activities that regulate these pathways. By influencing these pathways myotrophin plays a substantial role in cellular adaptation and stress response mechanisms.

Myotrophin associates with cardiovascular diseases like hypertrophic cardiomyopathy and heart failure. It contributes to the pathological remodeling of heart tissue through its impact on hypertrophy. Additionally it shows implications in neurodegenerative diseases linked through the protein α-synuclein. Alterations in myotrophin levels and function can disrupt normal cellular processes leading to the progression of these critical diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
See full target information MTPN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 7:351 PubMed31921861

2019

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhua Gao,Ranxi Zhang,Shanshan Dai,Xue Zhang,Xiangchen Li,Chunyu Bai
View all publications
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