Rabbit Polyclonal Myozenin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYOZ1.
IgG
Rabbit
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Expected | Tested |
Mouse | Tested | Expected |
Pig | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/500 - 1/2000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Pig | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/25 - 1/100 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Pig | Dilution info - | Notes - |
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
MYOZ, MYOZ1, Myozenin-1, Calsarcin-2, Protein FATZ
Rabbit Polyclonal Myozenin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYOZ1.
IgG
Rabbit
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Myozenin 1 also known as calsarcin-2 is a protein expressed mainly in skeletal muscle with a molecular weight of approximately 35 kDa. It connects protein structures at the Z-disks in muscle cells. Myozenin 1 links to other important muscle proteins such as alpha-actinin and gamma-filamin. Through these interactions it helps maintain structural integrity and transmission of force within muscle fibers.
The role of Myozenin 1 extends beyond structural support in muscle. It modulates signal transduction pathways essential for muscle function and adaptation. This protein forms part of a complex with calcineurin a phosphatase involved in muscle-specific gene expression control. By regulating calcineurin activity Myozenin 1 influences muscle fiber type composition and response to physiological stimuli.
Myozenin 1 participates in the calcineurin-NFAT signaling pathway which is a critical regulator of muscle development and adaptation. While Myozenin 1 itself interacts directly with calcineurin it also has indirect associations with proteins like NFAT that mediate its downstream effects. These pathways play important roles in muscle plasticity and response to mechanical stress.
Alterations in Myozenin 1 expression or function may relate to conditions such as muscle weakness and hypertrophic cardiomyopathy. Myozenin 1 interacts with proteins like calcineurin and disruptions in this relationship can lead to abnormal muscle signaling and pathological changes. Research continues to explore the direct contributions of Myozenin 1 to muscle-related diseases and their underlying molecular mechanisms.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
10+12% SDS-PAGE.
All lanes: Western blot - Anti-Myozenin 1 antibody (ab197660) at 1/500 dilution
All lanes: Mouse muscle tissue lysate at 40 µg
Predicted band size: 32 kDa
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Myozenin 1 with ab197660 at 1/25 dilution.
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