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Rabbit Polyclonal Myozenin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYOZ1.

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Images

Western blot - Anti-Myozenin 1 antibody (AB197660), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 1 antibody (AB197660), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human MYOZ1. Database link Q9NP98

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Expected
Tested
Mouse
Tested
Expected
Pig
Predicted
Predicted

Tested
Tested

Species

Mouse

Dilution info

1/500 - 1/2000

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Pig

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/25 - 1/100

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Pig

Dilution info

-

Notes

-

Target data

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Alternative names

Recommended products

Rabbit Polyclonal Myozenin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYOZ1.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human MYOZ1. Database link Q9NP98
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Myozenin 1 also known as calsarcin-2 is a protein expressed mainly in skeletal muscle with a molecular weight of approximately 35 kDa. It connects protein structures at the Z-disks in muscle cells. Myozenin 1 links to other important muscle proteins such as alpha-actinin and gamma-filamin. Through these interactions it helps maintain structural integrity and transmission of force within muscle fibers.

Biological function summary

The role of Myozenin 1 extends beyond structural support in muscle. It modulates signal transduction pathways essential for muscle function and adaptation. This protein forms part of a complex with calcineurin a phosphatase involved in muscle-specific gene expression control. By regulating calcineurin activity Myozenin 1 influences muscle fiber type composition and response to physiological stimuli.

Pathways

Myozenin 1 participates in the calcineurin-NFAT signaling pathway which is a critical regulator of muscle development and adaptation. While Myozenin 1 itself interacts directly with calcineurin it also has indirect associations with proteins like NFAT that mediate its downstream effects. These pathways play important roles in muscle plasticity and response to mechanical stress.

Associated diseases and disorders

Alterations in Myozenin 1 expression or function may relate to conditions such as muscle weakness and hypertrophic cardiomyopathy. Myozenin 1 interacts with proteins like calcineurin and disruptions in this relationship can lead to abnormal muscle signaling and pathological changes. Research continues to explore the direct contributions of Myozenin 1 to muscle-related diseases and their underlying molecular mechanisms.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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2 product images

  • Western blot - Anti-Myozenin 1 antibody (ab197660), expandable thumbnail

    Western blot - Anti-Myozenin 1 antibody (ab197660)

    10+12% SDS-PAGE.

    All lanes: Western blot - Anti-Myozenin 1 antibody (ab197660) at 1/500 dilution

    All lanes: Mouse muscle tissue lysate at 40 µg

    Predicted band size: 32 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 1 antibody (ab197660), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 1 antibody (ab197660)

    Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Myozenin 1 with ab197660 at 1/25 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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