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Rabbit Polyclonal MYPOP antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYPOP aa 100-250.

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Images

Immunocytochemistry/ Immunofluorescence - Anti-MYPOP antibody (AB221487), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human MYPOP aa 100-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q86VE0

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICC/IF
Human
Tested

Tested
Tested

Species

Human

Dilution info

0.25000-2.00000 µg/mL

Notes

Fixation/Permeabilization: PFA/Triton X-100.

Target data

Function

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Alternative names

P42POP, P42POP, MYPOP, Myb-related protein p42POP, Partner of profilin

Recommended products

Rabbit Polyclonal MYPOP antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYPOP aa 100-250.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human MYPOP aa 100-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q86VE0
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MYPOP also known as Myb-related transcription factor is a DNA-binding protein involved in transcriptional regulation. It has a molecular mass of approximately 68 kDa. This protein localizes mainly in the nucleus where it binds DNA to influence gene expression. MYPOP is expressed in various human tissues most notably in the immune and hematopoietic systems indicating its importance in immune regulation.

Biological function summary

MYPOP acts as a transcription factor influencing cell proliferation and differentiation. It does not function alone but forms part of larger transcriptional complexes. By interacting with other transcriptional regulators it modulates the expression of genes necessary for cell cycle progression and hematopoietic processes. MYPOP holds a significant role in the maintenance of normal cellular functions and the immune response.

Pathways

MYPOP participates in essential transcriptional and immune signaling pathways. It is involved in the regulation of the p53 signaling pathway which is known for its role in controlling cell cycle and apoptosis. MYPOP shows interactions with related proteins such as Myb and p53 coordinating transcriptional responses critical for DNA damage repair and maintaining genomic integrity.

Associated diseases and disorders

MYPOP links to conditions such as leukemia and lymphoma. Its dysregulation affects cellular proliferation and survival contributing to hematological malignancies. Proteins like Myb which also influence transcription show a connection to MYPOP in these disorders as they cooperate in pathways that when altered lead to abnormal cell growth and cancer development. Understanding MYPOP's role could help in developing targeted therapies for these diseases.

Product promise

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1 product image

  • Immunocytochemistry/ Immunofluorescence - Anti-MYPOP antibody (ab221487), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-MYPOP antibody (ab221487)

    Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized A549 cells labeling MYPOP with ab221487 at 4 μg/ml (green).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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