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AB221487

Anti-MYPOP antibody

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(1 Publication)

Rabbit Polyclonal MYPOP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYPOP aa 100-250.

View Alternative Names

P42POP, MYPOP, Myb-related protein p42POP, Partner of profilin

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-MYPOP antibody (AB221487)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MYPOP antibody (AB221487)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized A549 cells labeling MYPOP with ab221487 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MYPOP aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q86VE0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MYPOP also known as Myb-related transcription factor is a DNA-binding protein involved in transcriptional regulation. It has a molecular mass of approximately 68 kDa. This protein localizes mainly in the nucleus where it binds DNA to influence gene expression. MYPOP is expressed in various human tissues most notably in the immune and hematopoietic systems indicating its importance in immune regulation.
Biological function summary

MYPOP acts as a transcription factor influencing cell proliferation and differentiation. It does not function alone but forms part of larger transcriptional complexes. By interacting with other transcriptional regulators it modulates the expression of genes necessary for cell cycle progression and hematopoietic processes. MYPOP holds a significant role in the maintenance of normal cellular functions and the immune response.

Pathways

MYPOP participates in essential transcriptional and immune signaling pathways. It is involved in the regulation of the p53 signaling pathway which is known for its role in controlling cell cycle and apoptosis. MYPOP shows interactions with related proteins such as Myb and p53 coordinating transcriptional responses critical for DNA damage repair and maintaining genomic integrity.

MYPOP links to conditions such as leukemia and lymphoma. Its dysregulation affects cellular proliferation and survival contributing to hematological malignancies. Proteins like Myb which also influence transcription show a connection to MYPOP in these disorders as they cooperate in pathways that when altered lead to abnormal cell growth and cancer development. Understanding MYPOP's role could help in developing targeted therapies for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).
See full target information MYPOP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Vaccines 8: PubMed32046307

2020

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Artigas-Jerónimo,Juan J Pastor Comín,Margarita Villar,Marinela Contreras,Pilar Alberdi,Israel León Viera,Leandro Soto,Raúl Cordero,James J Valdés,Alejandro Cabezas-Cruz,Agustín Estrada-Peña,José de la Fuente
View all publications
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Product promise

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