Anti-Myt1/MTF1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Myt1 also known as Membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase is a part of the Myt family of serine/threonine protein kinases. The molecular weight of Myt1 is approximately 58 kDa. Myt1 is expressed in several tissues with higher levels observed in the central nervous system. This protein is known for regulating cell cycle progression particularly during the G2/M transition by phosphorylating cyclin-dependent kinases.

Biological function summary

Myt1 plays a significant role in the control of cell cycle checkpoints. It forms part of a larger regulatory complex involving other kinases such as Wee1 to ensure proper cell division by preventing premature entry into mitosis. Myt1 achieves this by inactivating CDK1 through phosphorylation which is a critical step in maintaining cell cycle integrity in response to cellular stresses and DNA damage.

Pathways

Myt1 integrates into the cell cycle regulation pathway impacting the G2/M checkpoint pathways. It functions alongside Wee1 and related kinases to exert fine control over mitotic entry ensuring that any damaged DNA is repaired before the cell divides. Myt1's actions are important for proper cell cycle progression and maintaining genomic stability making it an important player in the processes that govern cellular proliferation.

Associated diseases and disorders

Myt1 has associations with various cancers due to its role in controlling cell division. When Myt1 function is disrupted it can lead to unchecked cell proliferation and tumorigenesis. Studies also connect Myt1 with Neurodevelopmental Disorders as its expression patterns affect neuronal differentiation and development. In these contexts Myt1 interacts with proteins like Wee1 highlighting its involvement in pathological states where cell cycle dysregulation and improper development take place.