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AB139732

Anti-MyT1L antibody

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(2 Publications)

Rabbit Polyclonal MYT1L antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MYT1L.

View Alternative Names

KIAA1106, MYT1L, Myelin transcription factor 1-like protein, MyT1-L, MyT1L

1 Images
Western blot - Anti-MyT1L antibody (AB139732)
  • WB

Unknown

Western blot - Anti-MyT1L antibody (AB139732)

All lanes:

Western blot - Anti-MyT1L antibody (ab139732) at 1 µg/mL

Lane 1:

Mouse Brain Tissue Lysate

Lane 2:

Mouse Brain Tissue Lysate with blocking peptide

Predicted band size: 133 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MYT1L. The exact immunogen used to generate this antibody is proprietary information.

Q9UL68

Specificity

At least three isoforms are known to exist. ab139732 will only recognize the two longest isoforms.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MyT1L also known as Myelin Transcription Factor 1-like is a transcription factor with a mass of about 125 kDa. It functions mechanically as a DNA-binding protein regulating the expression of specific target genes. You will find MyT1L expressed in the central nervous system including the brain and spinal cord. Its expression also extends to other tissues but is lower compared to neural tissues.
Biological function summary

MyT1L plays a role in neuronal differentiation impacting the development of neural progenitor cells into mature neurons. It does not function as part of a larger protein complex. Instead MyT1L acts independently primarily controlling the transcriptional regulation of genes involved in neuronal development. Its action ensures proper neuronal specification and plasticity critical in forming functional neural networks.

Pathways

MyT1L participates in neurogenesis and central nervous system development pathways. It interacts with proteins like MyT1 and other neurogenic factors orchestrating the intricate processes of neural lineage commitment. MyT1L's involvement in the Notch signaling pathway although less explored may coordinate with these proteins to regulate the fate of neural precursor cells.

MyT1L shows links to neurological conditions such as epilepsy and intellectual disabilities. Changes in MyT1L expression or activity suggest potential disruptions in neural differentiation contributing to these disorders. In epilepsy for instance MyT1L might interact with proteins like MyT1 which could influence the electrical activity balance in neural circuits and lead to the disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
See full target information MYT1L
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature biomedical engineering 4:69-83 PubMed31844155

2019

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaogang Yang,Junfeng Shi,Jing Xie,Yifan Wang,Jingyao Sun,Tongzheng Liu,Yarong Zhao,Xiuting Zhao,Xinmei Wang,Yifan Ma,Veysi Malkoc,Chiling Chiang,Weiye Deng,Yuanxin Chen,Yuan Fu,Kwang J Kwak,Yamin Fan,Chen Kang,Changcheng Yin,June Rhee,Paul Bertani,Jose Otero,Wu Lu,Kyuson Yun,Andrew S Lee,Wen Jiang,Lesheng Teng,Betty Y S Kim,L James Lee

International journal of molecular medicine 41:717-728 PubMed29207083

2017

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.

Applications

WB

Species

Rat

Masaki Hiramoto,Haruhide Udagawa,Naoko Ishibashi,Eri Takahashi,Yasushi Kaburagi,Keisuke Miyazawa,Nobuaki Funahashi,Takao Nammo,Kazuki Yasuda
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Product promise

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