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AB229494

Anti-MyT1L antibody

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(1 Publication)

Rabbit Polyclonal MYT1L antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYT1L.

View Alternative Names

KIAA1106, MYT1L, Myelin transcription factor 1-like protein, MyT1-L, MyT1L

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-MyT1L antibody (AB229494)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MyT1L antibody (AB229494)

4% paraformaldehyde-fixed NTERA-2 cl.D1 [NT2/D1] (human malignant pluripotent embryonic carcinoma cell line) stained for MyT1L with ab229494 at1/500 dilution in ICC/IFF.

Nuclear counterstain : Hoechst 33342 (blue).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MYT1L. The exact immunogen used to generate this antibody is proprietary information.

Q9UL68

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MyT1L also known as Myelin Transcription Factor 1-like is a transcription factor with a mass of about 125 kDa. It functions mechanically as a DNA-binding protein regulating the expression of specific target genes. You will find MyT1L expressed in the central nervous system including the brain and spinal cord. Its expression also extends to other tissues but is lower compared to neural tissues.
Biological function summary

MyT1L plays a role in neuronal differentiation impacting the development of neural progenitor cells into mature neurons. It does not function as part of a larger protein complex. Instead MyT1L acts independently primarily controlling the transcriptional regulation of genes involved in neuronal development. Its action ensures proper neuronal specification and plasticity critical in forming functional neural networks.

Pathways

MyT1L participates in neurogenesis and central nervous system development pathways. It interacts with proteins like MyT1 and other neurogenic factors orchestrating the intricate processes of neural lineage commitment. MyT1L's involvement in the Notch signaling pathway although less explored may coordinate with these proteins to regulate the fate of neural precursor cells.

MyT1L shows links to neurological conditions such as epilepsy and intellectual disabilities. Changes in MyT1L expression or activity suggest potential disruptions in neural differentiation contributing to these disorders. In epilepsy for instance MyT1L might interact with proteins like MyT1 which could influence the electrical activity balance in neural circuits and lead to the disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
See full target information MYT1L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:692265 PubMed35083134

2022

LINC00883 Promotes Drug Resistance of Glioma Through a microRNA-136/NEK1-Dependent Mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Yongzhe Li,Xin Gao
View all publications
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