Skip to main content

Rabbit Polyclonal N Cadherin antibody. Suitable for WB, IHC - Wmt and reacts with Zebrafish samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish cdh2 aa 100-350.

Be the first to review this product! Submit a review

Images

IHC - Wholemount - Anti-N Cadherin antibody (AB211126), expandable thumbnail
  • IHC - Wholemount - Anti-N Cadherin antibody (AB211126), expandable thumbnail
  • Western blot - Anti-N Cadherin antibody (AB211126), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Zebrafish cdh2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q90275

Consider this alternative

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC - Wmt
Zebrafish
Tested
Tested

Tested
Tested

Species

Zebrafish

Dilution info

1/500 - 1/3000

Notes

-

Tested
Tested

Species

Zebrafish

Dilution info

1/50 - 1/500

Notes

-

Associated Products

Select an associated product type

7 products for Alternative Product

Target data

Function

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (PubMed:12091300). Required for normal neural tube morphogenesis (PubMed:12091300, PubMed:21115806). Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain (PubMed:14648850, PubMed:21115806). Functions with protocadherin pcdh19 to coordinate cell adhesion and cell movements during neurulation (PubMed:21115806). pcdh19 shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex (PubMed:21115806, PubMed:22184198, PubMed:33004519). Contributes to neural progenitor cell patterning by promoting homophilic cell interactions (PubMed:33004519). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal N Cadherin antibody. Suitable for WB, IHC - Wmt and reacts with Zebrafish samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish cdh2 aa 100-350.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Zebrafish cdh2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q90275
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

N-Cadherin also known as CDH2 or neuronal cadherin is a calcium-dependent cell adhesion protein. It is characterized by its role in mediating intercellular connections primarily through its presence on neurons fibroblasts and certain epithelial cells. N-Cadherin has an approximate mass of 130 kDa. The protein is integral in forming homophilic interactions where N-Cadherin molecules on adjacent cells interact to establish robust cell-cell adhesion.

Biological function summary

N-Cadherin significantly influences cell-cell interaction and communication facilitating cellular adhesion and signal transduction. It is a vital component of adherens junctions contributing to tissue morphogenesis and stability. N-Cadherin interacts with other cytoplasmic proteins such as catenins forming a complex essential for linking the actin cytoskeleton to the cell membrane. This interaction affects cellular behaviors including migration and differentiation.

Pathways

N-Cadherin plays a significant role in the neural development and epithelial-to-mesenchymal transition (EMT) pathways important for development and cancer progression. It engages with related proteins such as beta-catenin which helps transduce signals within these pathways. N-Cadherin's interactions within these pathways highlight its role in maintaining multicellular structure and signaling processes important for development and pathogenesis.

Associated diseases and disorders

N-Cadherin is associated with cancer and heart disease. In cancer particularly in the context of the EMT N-Cadherin facilitates tumor progression and metastasis cooperating with proteins like Twist and Snail to promote these processes. In heart disease alterations in N-Cadherin expression and function can impact cardiac muscle integrity and syncytium highlighting potential interactions with connexin43 to maintain cardiac function. Understanding these associations provides insights into therapeutic targets for these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • IHC - Wholemount - Anti-N Cadherin antibody (ab211126), expandable thumbnail

    IHC - Wholemount - Anti-N Cadherin antibody (ab211126)

    Immunohistochemical analysis (wholemount) of 2 days-post-fertilization zebrafish embryo labeling N Cadherin with ab211126 at 1/50 dilution.

  • IHC - Wholemount - Anti-N Cadherin antibody (ab211126), expandable thumbnail

    IHC - Wholemount - Anti-N Cadherin antibody (ab211126)

    Immunohistochemical analysis (wholemount) of 2 days-post-fertilization zebrafish embryo labeling N Cadherin with ab211126 at 1/50 dilution.

  • Western blot - Anti-N Cadherin antibody (ab211126), expandable thumbnail

    Western blot - Anti-N Cadherin antibody (ab211126)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-N Cadherin antibody (ab211126) at 1/1000 dilution

    All lanes: Zebrafish brain whole cell lysate at 30 µg

    Predicted band size: 99 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com