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AB236991

Anti-NAALADL2 antibody

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Rabbit Polyclonal NAALADL2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NAALADL2 aa 100 to C-terminus.

View Alternative Names

Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2, NAALADase L2, NAALADL2

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAALADL2 antibody (AB236991)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAALADL2 antibody (AB236991)

Paraffin-embedded human placenta tissue stained for NAALADL2 using ab236991 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-NAALADL2 antibody (AB236991)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NAALADL2 antibody (AB236991)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling NAALADL2 (green) using ab236991 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG (H+L).

Western blot - Anti-NAALADL2 antibody (AB236991)
  • WB

Supplier Data

Western blot - Anti-NAALADL2 antibody (AB236991)

All lanes:

Western blot - Anti-NAALADL2 antibody (ab236991) at 1/2000 dilution

All lanes:

A549 (human lung carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 89 kDa

false

Western blot - Anti-NAALADL2 antibody (AB236991)
  • WB

Supplier Data

Western blot - Anti-NAALADL2 antibody (AB236991)

All lanes:

Western blot - Anti-NAALADL2 antibody (ab236991) at 1/2000 dilution

Lane 1:

Mouse lung lysate

Lane 2:

Mouse kidney lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 89 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NAALADL2 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q58DX5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NAALADL2 also known as N-acetylated alpha-linked acidic dipeptidase-like 2 functions mechanically as a type II transmembrane glycoprotein. It participates in peptide hydrolysis and it is related to the prostate-specific membrane antigen (PSMA) family. The protein has an approximate mass of 85 kDa. Researchers have observed its expression in several tissues with a higher presence in the prostate and certain reproductive tissues. The protein also localizes in the epithelial cells where it potentially plays a role in modulating peptide signaling.
Biological function summary

NAALADL2 is involved in controlling levels of N-acetylaspartylglutamate a neuropeptide that functions as a neurotransmitter. Despite its mechanical similarity to PSMA NAALADL2 does not participate in the folate metabolism. Instead its role centers around peptide processing and regulation without being known as part of a specific protein complex. Its actions in the hydrolysis of peptide bonds affect neural communication and possibly cellular signaling in the tissue where it is expressed.

Pathways

Peptide metabolism and hydrolysis are important processes in which NAALADL2 is involved. It is linked to pathways governing neurotransmitter regulation and could impact excitatory signaling in neurons through its regulation of peptide intermediates. In these pathways NAALADL2 is related to proteins that manage neurotransmitter dynamics like NAALADase due to similarities in their functions and regulatory roles.

Researchers have explored connections between NAALADL2 and prostate cancer. Elevated levels of this protein occur in certain prostate cancer types suggesting a role in cancer progression or development. The protein shares similarity with PSMA which has established roles in prostate cancer pathology. Understanding this relationship could lead to targeted therapeutic interventions focusing on modulating its expression or activity. Additionally scientists consider its neuropeptide interaction in the context of neural disorders although more research is necessary to elucidate any direct links.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be catalytically inactive.
See full target information NAALADL2
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Product promise

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