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AB106661

Anti-NABC1 antibody

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(6 Publications)

Rabbit Polyclonal NABC1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human BCAS1.

View Alternative Names

AIBC1, NABC1, BCAS1, Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-NABC1 antibody (AB106661)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-NABC1 antibody (AB106661)

Immunofluorescence of BCAS1 in Human Breast Carcinoma cells using ab106661 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NABC1 antibody (AB106661)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NABC1 antibody (AB106661)

ab106661, at 5μg/ml, staining NABC1 in Human breast carcinoma tissue by Immunohistochemistry.

Western blot - Anti-NABC1 antibody (AB106661)
  • WB

Unknown

Western blot - Anti-NABC1 antibody (AB106661)

All lanes:

Western blot - Anti-NABC1 antibody (ab106661) at 1 µg/mL

All lanes:

Human lung tissue lysate at 15 µg

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human BCAS1. The exact immunogen used to generate this antibody is proprietary information.

O75363

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NABC1 also known as New ABC Transporter 1 is an ATP-binding cassette transporter protein with a molecular mass of around 160 kDa. Mechanically NABC1 functions as a transporter utilizing the energy from ATP hydrolysis to move lipids across cellular membranes. This protein is widely expressed in many tissues particularly in liver kidneys and intestines. Its transport activity plays a central role in maintaining cellular lipid homeostasis.
Biological function summary

NABC1 influences lipid metabolism by mediating the efflux of cholesterol and phospholipids from cells to lipid-poor apolipoproteins. It is not part of a larger protein complex but interacts dynamically with extracellular and membrane-associated proteins to facilitate lipid transport. These interactions are important for preventing lipid accumulation within cells which is essential for cellular health and normal functioning.

Pathways

NABC1 participates in the reverse cholesterol transport pathway and is integral to the regulation of cholesterol levels. It works closely with proteins such as apolipoprotein A-I to facilitate cholesterol removal from peripheral tissues thereby contributing to the overall cholesterol homeostasis. This pathway helps to prevent the buildup of excess cholesterol and protects against atherosclerosis.

Abnormal NABC1 activity links to conditions like Tangier disease and familial HDL deficiency where lipid transport becomes impaired. Mutations in NABC1 lead to reduced or absent transporter activity resulting in very low levels of HDL cholesterol in the blood. This defect causes cholesterol to accumulate in tissues causing complications associated with these disorders. NABC1's role in these conditions highlights its interaction with other proteins involved in lipid metabolism and cholesterol transport.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for myelination.
See full target information BCAS1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

GeroScience 45:249-264 PubMed35930094

2022

Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Dimovasili,Ashley E Fair,Isabella R Garza,Katelyn V Batterman,Farzad Mortazavi,Tara L Moore,Douglas L Rosene

Nature communications 13:2445 PubMed35508608

2022

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination.

Applications

Unspecified application

Species

Unspecified reactive species

Samira Ghorbani,Emily Jelinek,Rajiv Jain,Benjamin Buehner,Cenxiao Li,Brian M Lozinski,Susobhan Sarkar,Deepak K Kaushik,Yifei Dong,Thomas N Wight,Soheila Karimi-Abdolrezaee,Geert J Schenk,Eva M Strijbis,Jeroen Geurts,Ping Zhang,Chang-Chun Ling,V Wee Yong

Acta neuropathologica communications 8:224 PubMed33357244

2020

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination.

Applications

Unspecified application

Species

Unspecified reactive species

Melanie Lohrberg,Anne Winkler,Jonas Franz,Franziska van der Meer,Torben Ruhwedel,Nikoloz Sirmpilatze,Rakshit Dadarwal,Ronja Handwerker,Daniel Esser,Kerstin Wiegand,Christian Hagel,Andreas Gocht,Fatima Barbara König,Susann Boretius,Wiebke Möbius,Christine Stadelmann,Alonso Barrantes-Freer

Experimental neurology 337:113540 PubMed33264634

2020

Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.

Applications

Unspecified application

Species

Unspecified reactive species

Veronica Go,Deniz Sarikaya,Yuxin Zhou,Bethany G E Bowley,Monica A Pessina,Douglas L Rosene,Zheng Gang Zhang,Michael Chopp,Seth P Finklestein,Maria Medalla,Benjamin Buller,Tara L Moore

Scientific reports 7:14518 PubMed29109530

2017

A clinical-scale BioArtificial Liver, developed for GMP, improved clinical parameters of liver function in porcine liver failure.

Applications

Unspecified application

Species

Unspecified reactive species

Clare Selden,James Bundy,Eloy Erro,Eva Puschmann,Malcolm Miller,Delawir Kahn,Humphrey Hodgson,Barry Fuller,Jordi Gonzalez-Molina,Aurelie Le Lay,Stephanie Gibbons,Sherri Chalmers,Sunil Modi,Amy Thomas,Peter Kilbride,Agnes Isaacs,Richard Ginsburg,Helen Ilsley,David Thomson,Galya Chinnery,Ncedile Mankahla,Lizel Loo,C Wendy Spearman

Proteomics 13:2113-24 PubMed23595970

2013

Temozolomide-modulated glioma proteome: role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivity.

Applications

Unspecified application

Species

Unspecified reactive species

Durairaj M Kumar,Vikas Patil,Bini Ramachandran,Murugesan V Nila,Kuppamuthu Dharmalingam,Kumaravel Somasundaram
View all publications
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