Anti-Nac1 antibody [PCRP-NACC1-1A8]
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(1 Publication)
Mouse Monoclonal Nac1 antibody. Suitable for Flow Cyt, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NACC1.
View Alternative Names
BTBD14B, NAC1, NACC1, Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B
- Flow Cyt
Supplier Data
Flow Cytometry - Anti-Nac1 antibody [PCRP-NACC1-1A8] (AB277093)
Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling Nac1 using ab277093 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
- Protein Array
Unknown
Protein Array - Anti-Nac1 antibody [PCRP-NACC1-1A8] (AB277093)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab277093.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Properties and storage information
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Purification technique
Purification notes
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Shipped at conditions
Appropriate short-term storage duration
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Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Nac1 protein plays a significant role in embryonic development and maintaining cell pluripotency. It forms a complex with several chromatin remodeling proteins assisting in the regulation of gene transcription. This involvement suggests its function is important in early developmental stages and in cells that require extensive plasticity. Besides Nac1 affects the cellular response to external stress stimuli contributing to cell survival under adverse conditions.
Pathways
The Nac1 protein integrates into the Hedgehog signaling pathway and the ubiquitin-proteasome pathway. In the Hedgehog pathway Nac1 influences gene regulation that is essential for cellular differentiation and tissue development. In the ubiquitin-proteasome pathway Nac1 interacts with proteins such as Skp1 and Cullin1 which are part of the SCF complex to modulate protein degradation.
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Target data
Publications (1)
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Materials today. Bio 34:102234 PubMed40893347
2025
Applications
Unspecified application
Species
Unspecified reactive species
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