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AB316952

Anti-NaDC-3 antibody

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Rabbit Polyclonal NaDC-3 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC13A3.

View Alternative Names

NADC3, SDCT2, SLC13A3, Na(+)/dicarboxylate cotransporter 3, NaDC-3, hNaDC3, Na(+)-coupled carboxylate transporter 3, Sodium-dependent high-affinity dicarboxylate transporter 2, Solute carrier family 13 member 3, NaC3

1 Images
Western blot - Anti-NaDC-3 Antibody (AB316952)
  • WB

Supplier Data

Western blot - Anti-NaDC-3 Antibody (AB316952)

Gel : 8%SDS-PAGE

All lanes:

Western blot - Anti-NaDC-3 Antibody (ab316952) at 1/200 dilution

Lane 1:

Human placenta tissue at 40 µg

Lane 2:

Human plasma at 40 µg

Secondary

All lanes:

Goat anti rabbit IgG at 1/8000 dilution

Predicted band size: 67 kDa

false

Exposure time: 2min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SLC13A3.

Q8WWT9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C|-80°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NaDC-3 also known as SLC13A3 is a sodium-dependent dicarboxylate transporter with a mass of approximately 61 kDa. It facilitates the transport of dicarboxylates such as succinate and alpha-ketoglutarate across cell membranes in a sodium-coupled manner. NaDC-3 is widely expressed in various tissues including the kidneys liver and brain. Its mechanical function involves using the sodium gradient established by the Na+/K+ ATPase to drive the uptake of dicarboxylates into cells which plays a critical role in maintaining cellular metabolism and function.
Biological function summary

NaDC-3 contributes significantly to cellular metabolism by enabling the import of key dicarboxylates necessary for the citric acid cycle. Although not a part of a larger protein complex this transporter plays a role in energy production and intermediate metabolism. In tissues like the kidney NaDC-3 maintains the reabsorption of dicarboxylates supporting electrolyte balance and nutrient reclamation. The transport activity also influences the metabolic flux and contributes to the energy homeostasis.

Pathways

NaDC-3 is a part of key metabolic processes including the citric acid cycle and the transport of organic anions. It operates alongside other transporters and enzymes to ensure efficient energy production through the Krebs cycle. NaDC-3 links closely with proteins involved in the sodium dicarboxylate cotransporter family such as NaDC-1 (SLC13A2) contributing to the regulation of sodium and dicarboxylate levels thereby impacting metabolic and renal homeostasis.

Altered function or expression of NaDC-3 associates with renal tubular acidosis and potential implications in metabolic disorders. Renal tubular acidosis often results from impaired reabsorption capabilities where NaDC-3's function impacts acid-base balance. Additionally disturbances in dicarboxylate metabolism may link NaDC-3 to disorders involving energy metabolism. Furthermore NaDC-3's interaction with other renal transporters may affect susceptibility to and progression of these diseases influencing clinical outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed : 10794676, PubMed : 10992006, PubMed : 15561973, PubMed : 17356845, PubMed : 17426067, PubMed : 24247155, PubMed : 30635937). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed : 10794676, PubMed : 10992006). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed : 10794676).
See full target information SLC13A3
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