Anti-NaDC-3 Antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NaDC-3 also known as SLC13A3 is a sodium-dependent dicarboxylate transporter with a mass of approximately 61 kDa. It facilitates the transport of dicarboxylates such as succinate and alpha-ketoglutarate across cell membranes in a sodium-coupled manner. NaDC-3 is widely expressed in various tissues including the kidneys liver and brain. Its mechanical function involves using the sodium gradient established by the Na+/K+ ATPase to drive the uptake of dicarboxylates into cells which plays a critical role in maintaining cellular metabolism and function.

Biological function summary

NaDC-3 contributes significantly to cellular metabolism by enabling the import of key dicarboxylates necessary for the citric acid cycle. Although not a part of a larger protein complex this transporter plays a role in energy production and intermediate metabolism. In tissues like the kidney NaDC-3 maintains the reabsorption of dicarboxylates supporting electrolyte balance and nutrient reclamation. The transport activity also influences the metabolic flux and contributes to the energy homeostasis.

Pathways

NaDC-3 is a part of key metabolic processes including the citric acid cycle and the transport of organic anions. It operates alongside other transporters and enzymes to ensure efficient energy production through the Krebs cycle. NaDC-3 links closely with proteins involved in the sodium dicarboxylate cotransporter family such as NaDC-1 (SLC13A2) contributing to the regulation of sodium and dicarboxylate levels thereby impacting metabolic and renal homeostasis.

Associated diseases and disorders

Altered function or expression of NaDC-3 associates with renal tubular acidosis and potential implications in metabolic disorders. Renal tubular acidosis often results from impaired reabsorption capabilities where NaDC-3's function impacts acid-base balance. Additionally disturbances in dicarboxylate metabolism may link NaDC-3 to disorders involving energy metabolism. Furthermore NaDC-3's interaction with other renal transporters may affect susceptibility to and progression of these diseases influencing clinical outcomes.