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AB230234

Anti-NAG-2 antibody

5

(2 Reviews)

|

(1 Publication)

Rabbit Polyclonal NAG-2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN4 aa 100 to C-terminus.

View Alternative Names

NAG2, TM4SF7, TSPAN4, Tetraspanin-4, Tspan-4, Novel antigen 2, Transmembrane 4 superfamily member 7, NAG-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAG-2 antibody (AB230234)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAG-2 antibody (AB230234)

Paraffin-embedded human prostate cancer tissue stained for NAG-2 with ab230234 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAG-2 antibody (AB230234)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAG-2 antibody (AB230234)

Paraffin-embedded human salivary gland tissue stained for NAG-2 with ab230234 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TSPAN4 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14817

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NAG-2 also known as Neuronal Apoptosis Inhibitory Protein 2 plays a critical role in inhibiting neuronal apoptosis. This protein weighs approximately 65 kDa and functions in the regulation of cell death mechanisms. NAG-2 is expressed extensively in the central nervous system encompassing regions such as the brain and spinal cord. It performs its mechanical function through interactions with molecules that modulate apoptosis signaling.
Biological function summary

NAG-2 inhibits key pathways that lead to apoptosis helping maintain neuronal survival and function. It often forms part of a larger protein complex involved in cell death pathways. Such a complex allows NAG-2 to influence other proteins that control cellular health and longevity. Its function holds importance in maintaining neural networks and their proper communication.

Pathways

Researchers have identified NAG-2 as playing a role in both the apoptotic signaling pathway and the Bcl-2 family pathway. NAG-2 interacts with other proteins such as Bcl-2 enhancing its anti-apoptotic effects. These interactions place NAG-2 as an important regulator within the cellular survival and apoptosis equilibrium allowing cells to resist unwanted death signals.

NAG-2 influences neurodegenerative conditions including Alzheimer's disease and Parkinson's disease. Dysregulation of NAG-2 function can lead to increased neuronal apoptosis contributing to the progression of these disorders. In Alzheimer's disease its association with proteins such as amyloid-beta indicates a potential therapeutic target for intervention strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed : 31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed : 31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed : 36252000, PubMed : 36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed : 34439793).
See full target information TSPAN4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 82:103613 PubMed40174478

2025

Repression of oxidative phosphorylation by NR2F2, MTERF3 and GDF15 in human skin under high-glucose stress.

Applications

Unspecified application

Species

Unspecified reactive species

S Ley-Ngardigal,S Claverol,L Sobilo,M Moreau,C Hubert,J Goupil,A Poulignon,W Mahfouf,H Fatrouni,L Dard,M Juan,L Gales,A Merched,C Tokarski,E Leblanc,A Galinier,D Lacombe,H R Rezvani,F Bellvert,K Pays,C Nizard,N Dias Amoedo,A L Bulteau,R Rossignol
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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