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AB234725

Anti-NBEAL2 antibody

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(1 Publication)

Rabbit Polyclonal NBEAL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NBEAL2 aa 1350-1600.

View Alternative Names

KIAA0540, UNQ253/PRO290, NBEAL2, Neurobeachin-like protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NBEAL2 antibody (AB234725)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NBEAL2 antibody (AB234725)

Paraffin-embedded human ovarian cancer tissue stained for NBEAL2 with ab234725 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-NBEAL2 antibody (AB234725)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NBEAL2 antibody (AB234725)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for NBEAL2 using ab234725 at a dilution of 1/100 in ICC/IF. Secondary antibody is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NBEAL2 aa 1350-1600. The exact immunogen used to generate this antibody is proprietary information.

Q6ZNJ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NBEAL2 protein also known as Neurobeachin-like 2 functions as a large protein with a mass of approximately 304 kDa. It has an important role in vesicle-mediated transport within cells. NBEAL2 is expressed mostly in hematopoietic tissues including bone marrow and peripheral blood. The protein structure includes a BEACH domain WD repeats and a leucine zipper motif which contribute to its involvement in cellular trafficking processes.
Biological function summary

The NBEAL2 protein plays an important role in platelet formation and maintenance. It appears necessary for the development of α-granules in platelets which are essential for proper blood clotting. These α-granules store numerous proteins such as clotting factors that are important in hemostasis. While NBEAL2 does not form its own complex it interacts with various cellular machinery involved in vesicle trafficking.

Pathways

NBEAL2 serves as a critical component in pathways regulating platelet production and release. Its functions intersect with the megakaryocyte development pathway an essential pathway for platelet biogenesis. NBEAL2 shows close interaction with proteins like WASP which also contribute to thrombopoiesis. Its activity ensures the proper formation and function of platelet precursor cells.

Several findings connect the NBEAL2 protein to gray platelet syndrome (GPS). GPS is a rare bleeding disorder characterized by the deficiency or absence of α-granules in platelets. Mutations in NBEAL2 are frequently linked to the development of this syndrome. Moreover the protein's role in platelet function also ties it to potential contributions in disorders related to thrombosis. Understanding NBEAL2's interactions especially with other proteins involved in platelet formation like MYH9 offers further insights into its implications in hematological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.
See full target information NBEAL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 24:508 PubMed39103807

2024

Identification and validation of genes associated with prognosis of cisplatin-resistant ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dajiang Liu,Ruiyun Li,Yidan Wang,Dan Li,Leilei Li
View all publications
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Product promise

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