Anti-NBR1 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NBR1 also known as Neighbor of BRCA1 Gene 1 functions as a receptor for selective autophagy. It recognizes ubiquitinated proteins and delivers them to autophagosomes for degradation. The protein has a molecular weight of approximately 110 kDa. Scientists have observed its expression in a variety of tissues with particularly high levels in the testis and low levels in the lung and kidney.

Biological function summary

NBR1 plays a significant role in the removal of misfolded or damaged proteins through autophagy. It acts within the p62/SQSTM1 complex which links to the autophagic machinery. The complex recruits ubiquitinated substrates facilitating their degradation in lysosomes. Through this mechanism NBR1 helps maintain cellular homeostasis and genome integrity by removing potentially harmful elements.

Pathways

NBR1 integrates into the critical cellular recycling process known as autophagy. It works closely with proteins such as p62/SQSTM1 in the ubiquitin-proteasome pathway to ensure efficient protein turnover. The protein participates in signals that control cell growth and survival influencing the mTOR pathway which is important in regulating cellular metabolism growth and life span.

Associated diseases and disorders

Research indicates that NBR1 might have implications in neurodegenerative diseases like Alzheimer's and Parkinson's. Its involvement in autophagy suggests that malfunction or aberrant expression of NBR1 could lead to the accumulation of protein aggregates associated with these conditions. Additionally interactions with proteins such as LC3 and p62/SQSTM1 central in lysosomal degradation highlight its potential role in disease mechanisms where autophagy is disrupted.