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AB110882

Anti-NCAPG2 antibody

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(1 Publication)

Rabbit Polyclonal NCAPG2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NCAPG2 aa 550-650.
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAPG2 antibody (AB110882)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAPG2 antibody (AB110882)

ab110882, at a 1/50 dilution, staining NCAPG2 in paraffin-embedded Human Lung carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human NCAPG2 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.

Q86XI2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab110882 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein NCAPG2 also known as Condensin-2 complex subunit G2 is important to the mechanical processes within cells. It plays an important role in mitosis and is part of the condensin II complex responsible for chromosome condensation and stabilization during cell division. NCAPG2 is a large protein with a mass of around 120 kDa. Expression is predominantly observed in proliferating tissues such as those in the bone marrow and thymus. This wide expression reveals its direct participation in fundamental cellular functions.
Biological function summary

The organism relies on NCAPG2 to ensure accurate chromosome segregation. As a component of the condensin II complex it collaborates with other subunits including NCAPD3 and SMC2. The protein's main task is to maintain the structural integrity of chromosomes allowing proper chromosome alignment during mitosis. This integrity is essential for genomic stability reducing the risks of aneuploidy.

Pathways

NCAPG2 is deeply involved in the regulation of the cell cycle. It takes part in both the mitotic prophase and anaphase pathways. Its function relates closely to other proteins like Cdc2 and Cyclin B which direct the progression of cell division. By integrating with structural pathways of chromosomes NCAPG2 becomes an important element in preventing mitotic errors and preserving cellular fidelity.

NCAPG2 has been linked to carcinogenesis and some developmental disorders. Aberrant expression or dysfunction of NCAPG2 is often observed in certain cancers such as breast and prostate cancer where genomic instability is a common characteristic. In cancerous conditions its interaction with proteins like p53—known for DNA damage response—becomes significant highlighting its potential role in tumorigenesis. Furthermore studies investigate its connection with developmental anomalies probing possible implications in aberrant cellular proliferation pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
See full target information NCAPG2

Alternative Names

LUZP5, NCAPG2, Condensin-2 complex subunit G2, Chromosome-associated protein G2, Leucine zipper protein 5, Non-SMC condensin II complex subunit G2, CAP-G2, hCAP-G2
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

European journal of human genetics : EJHG 23:1080-4 PubMed25370038

2014

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fadwa A Elsayed,C Marleen Kets,Dina Ruano,Brendy van den Akker,Arjen R Mensenkamp,Melanie Schrumpf,Maartje Nielsen,Juul T Wijnen,Carli M Tops,Marjolijn J Ligtenberg,Hans F A Vasen,Frederik J Hes,Hans Morreau,Tom van Wezel
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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