JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB89877

Anti-NCR1/NKp46 antibody [MM0491-8F24]

5

(4 Reviews)

|

(2 Publications)

Mouse Monoclonal NCR1 antibody. Carrier free. Suitable for Flow Cyt, WB, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NCR1.

View Alternative Names

CD335, LY94, NCR1, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, NKp46, hNKp46

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0491-8F24

Isotype

IgG2b

Carrier free

Yes

Reacts with

Human

Applications

WB, Flow Cyt, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Human NCR1. The exact immunogen used to generate this antibody is proprietary information.

O76036

style
left-column

Alternative Products

Primary Antibodies

AB14823

Anti-NCR1/NKp46 antibody [n1D9]

Flow Cytometry - Anti-NCR1/NKp46 antibody [n1D9] (AB14823)

  • 0
  • 0
Primary Antibodies

AB233808

Anti-NCR1/NKp46 antibody [2B11E12]

Flow Cytometry - Anti-NCR1/NKp46 antibody [2B11E12] (AB233808)

  • 0
  • 0
Primary Antibodies

AB199128

Anti-NCR1/NKp46 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCR1/NKp46 antibody (AB199128)

  • 0
  • 0
Primary Antibodies

AB214468

Anti-NCR1/NKp46 antibody

Western blot - Anti-NCR1/NKp46 antibody (AB214468)

  • 4
  • 4

Complementary Products

Assay Kits

AB282310

Human NCR1/NKp46 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human NCR1/NKp46 ELISA Kit (AB282310)

  • 0
  • 0
Primary Antibodies

AB20034

Anti-FOXP3 antibody [236A/E7]

BOND RX™ Validated|Recombinant|Lab Essentials|Advanced Validation

Multiplex immunohistochemistry - Anti-FOXP3 antibody [236A/E7] (AB20034)

  • 4
  • 38
Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

  • 4
  • 80
Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB64088

Anti-CD20 antibody [SP32]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD20 antibody [SP32] (AB64088)

  • 5
  • 12
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg2b-kappa-monoclonal-7e10g10-isotype-control-ab170192'>ab170192</a> - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and sterile filtered through a 0.2 µm filter.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NCR1 also known as NKp46 is a receptor mainly expressed on the surface of natural killer (NK) cells. Its primary role involves recognizing and binding to ligands present on target cells including tumor cells and virus-infected cells. NCR1 initiates the activation of NK cells leading to the destruction of these abnormal cells. The NCR1 protein has a molecular weight of approximately 46 kDa and is a part of the immunoglobulin superfamily. NCR1 is mainly expressed in the immune system specifically on NK cells which are an important component of the innate immune response.
Biological function summary

The function of NCR1 involves the recognition of stressed transformed or infected cells marking them for elimination by NK cells. It does not typically function as a part of a complex; rather it serves a somewhat autonomous role in cell signaling. However its interaction with other receptors on NK cells including DAP12 enhances its signaling capabilities. Through the activation of cascades NCR1 promotes the release of cytotoxic granules and the production of cytokines therefore mediating the immune response.

Pathways

NCR1 plays a significant role in the regulation of immune surveillance pathways. It is involved in the recognition and elimination pathways that modulate the immune response against infected or cancerous cells. NK cells with NCR1's involvement interact with receptors like NKG2D adjusting the NK cell's cytotoxic activity. These interactions coordinate the broader immune response important for innate immunity effectively bridging innate and adaptive immunity by influencing other immune cells.

NCR1 has been implicated in cancer and infectious diseases. In cancer altered expression or dysfunction of NCR1 may contribute to the evasion of immune surveillance by tumor cells potentially leading to tumor progression. Studies have shown reduced NKp46 expression in some cancerous states linking it to poor prognosis. In infectious diseases NCR1 plays a role in targeting virus-infected cells and its dysfunction can result in reduced effectiveness in clearing viral infections. Interactions with viral envelope proteins can interfere with NCR1 activity exemplifying its importance in antiviral defense mechanisms.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
See full target information NCR1
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 65:38 PubMed39446353

2024

Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome.

Applications

Unspecified application

Species

Unspecified reactive species

Chunlian Ou,Yiwei Lin,Jing Wen,Hongyang Zhang,Ying Xu,Naiyuan Zhang,Qiong Liu,Yingzi Wu,Jing Xu,Jing Wu

The Journal of allergy and clinical immunology 143:2190-2201.e9 PubMed30682454

2019

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid.

Applications

Unspecified application

Species

Unspecified reactive species

Hideaki Morita,Terufumi Kubo,Beate Rückert,Avinash Ravindran,Michael B Soyka,Arturo Ottavio Rinaldi,Kazunari Sugita,Marcin Wawrzyniak,Paulina Wawrzyniak,Kenichiro Motomura,Masato Tamari,Keisuke Orimo,Naoko Okada,Ken Arae,Kyoko Saito,Can Altunbulakli,Francesc Castro-Giner,Ge Tan,Avidan Neumann,Katsuko Sudo,Liam O'Mahony,Kenya Honda,Susumu Nakae,Hirohisa Saito,Jenny Mjösberg,Gunnar Nilsson,Kenji Matsumoto,Mübeccel Akdis,Cezmi A Akdis
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com