Rabbit Polyclonal NDEL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human Nuclear distribution protein nudE-like 1.
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Publications
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- Cancer immunology research 11:792-8092023T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDiana Rasoulouniriana,Nadine Santana-Magal,Amit Gutwillig,Leen Farhat-Younis,Lior Tal,Sarah Amar,Michael Milyavsky,Siva Sai Naga Anurag Muddineni,Neta Solomon,Hana Shpilt,Shahar Dotan,Noam Pilpel,Claudia Waskow,Meora Feinmesser,Peleg Rider,Yaron CarmiPubMed 37070661
- Nature communications 10:2282019Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDail E Chapman et. al.PubMed 30651536
- Neuroscience 271:119-362014The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZ Pei et. al.PubMed 24785679
- The Journal of cell biology 204:1099-1092014SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.
- The Journal of pharmacology and experimental thera 327:137-472008The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.
- The Journal of neuroscience : the official journal of the Society for Neuroscience 28:3839-452008Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesS Rutger Leliveld,Verian Bader,Philipp Hendriks,Ingrid Prikulis,Gustavo Sajnani,Jesús R Requena,Carsten KorthPubMed 18400883
- Proceedings of the National Academy of Sciences of 104:18280-52007Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human Nuclear distribution protein nudE-like 1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9GZM8
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.50000-1.00000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2 µg/mL | Notes - |
Associated Products
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Target data
Function
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
Alternative names
Nuclear distribution protein nudE-like 1, Protein Nudel, Mitosin-associated protein 1, EOPA, NUDEL, MITAP1, NDEL1
Recommended products
Rabbit Polyclonal NDEL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human Nuclear distribution protein nudE-like 1.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human Nuclear distribution protein nudE-like 1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9GZM8
- Purification technique
Affinity purification Immunogen
- Specificity
ab25959 recognises NDEL1.
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NDEL1 also known as Nudel or nuclear distribution element-like 1 is a protein with a molecular mass of around 38 kDa. It plays a role mechanically by participating in microtubule and centrosome-related processes. In terms of expression NDEL1 is found in both the central nervous system and several peripheral tissues. Its localization relates to its function in cellular dynamics particularly involving the cytoskeleton.
- Biological function summary
NDEL1 interacts within a multi-protein complex called the dynein motor complex. This association is critical for the process of neuronal migration and axonal transport involving the movement of cellular components along microtubules. The protein acts as a linking agent facilitating microtubule assembly and organization which are essential for maintaining cellular structure and function.
- Pathways
The role of NDEL1 in cytoskeletal dynamics integrates into key pathways such as the cell cycle and neurodevelopmental processes. It interacts with proteins like LIS1 in the cell cycle pathway which affects mitosis. Moreover its interaction with dynein emphasizes its role in intracellular transport during neurodevelopment indicating its aosphysical involvement in brain architecture.
- Associated diseases and disorders
NDEL1 has a significant connection with neurodevelopmental disorders and neurodegenerative diseases. Its association with LIS1 and the disruption of their interaction contributes to lissencephaly a condition marked by smooth brain surface. Additionally alterations in NDEL1 function also connect with Alzheimer's disease due to its role in neuronal structural maintenance alongside proteins such as tau that become dysregulated.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-NDEL1 antibody (ab25959)
Lane 1: Western blot - Anti-NDEL1 antibody (ab25959) at 0.5 µg/mL
Lane 2: Western blot - Anti-NDEL1 antibody (ab25959) at 1 µg/mL
Lane 3: Western blot - Anti-NDEL1 antibody (ab25959) at 2 µg/mL
All lanes: Jurkat whole cell lysate.
Predicted band size: 38 kDa
Observed band size: 34 kDa
Immunocytochemistry/ Immunofluorescence - Anti-NDEL1 antibody (ab25959)
ab25959 at 2μg/ml staining NDEL1 in Jurkat cells by ICC/IF
Immunocytochemistry/ Immunofluorescence - Anti-NDEL1 antibody (ab25959)
Immunofluorescence of Nudel in Jurkat cells using ab25959 at 10 ug/ml.
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