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AB185715

Anti-NDP antibody

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Rabbit Polyclonal NDP antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NDP.

View Alternative Names

EVR2, NDP, Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein

1 Images
Western blot - Anti-NDP antibody (AB185715)
  • WB

Supplier Data

Western blot - Anti-NDP antibody (AB185715)

All lanes:

Western blot - Anti-NDP antibody (ab185715) at 1/500 dilution

Lane 1:

Mouse liver cell line extract

Lane 2:

Mouse heart cell line extract

Lane 3:

Mouse eye cell line extract

Predicted band size: 15 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NDP.

Q00604

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NDP also known as Norrin is a signaling protein with a mass of about 13 kDa. This protein plays an important role in cellular signaling involving the Wnt signaling pathway. NDP primarily expresses in the vascular tissues of the retina and cochlea where it influences their development and maintenance. It also shows expression in the brain suggesting its diverse roles beyond just ocular and auditory systems.
Biological function summary

NDP acts as a ligand that associates with the Frizzled-4 receptor and LRP5/6 to activate the Wnt/β-catenin signaling pathway. This activation leads to a variety of cellular responses such as cell proliferation and differentiation which are essential in vascular development. NDP exists within a complex that includes other Wnt pathway components ensuring precise regulation of these biological processes.

Pathways

The involvement of NDP in the Wnt/β-catenin signaling is significant for its regulation of vascular development and maintenance. It interacts with LRP5/6 and Frizzled-4 proteins within this pathway ensuring that endothelial cells form proper blood vessel structures. NDP also has implications within angiogenesis another vital pathway for the growth of new blood vessels enhancing the understanding of its function in vascular biology.

Abnormalities in NDP function link to Norrie disease and familial exudative vitreoretinopathy. These conditions result from improper blood vessel development in the retina leading to vision loss and other ocular complications. The interaction of NDP with related proteins like Frizzled-4 suggests its unbalanced regulation may contribute significantly to these disorders. Understanding NDP's relationship with these proteins aids in developing therapeutic strategies targeting its signaling pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
See full target information NDP
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