Anti-NDST2 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NDST2 also known as N-deacetylase/N-sulfotransferase 2 is an enzyme with a mass of roughly 100 kDa. This enzyme participates in the modification of heparan sulfate proteoglycans by catalyzing the N-deacetylation and subsequent N-sulfation of glucosamine residues. NDST2 expression occurs widely in many tissues including the brain kidney and lung. Its activity is necessary for the maturation of heparan sulfate chains which play important roles in various cellular processes.

Biological function summary

NDST2 modifies heparan sulfate proteoglycans which affects cell signaling and interactions. This enzyme functions independently but its product the modified heparan sulfate interacts with other molecules to form complex networks essential for biological activities. NDST2’s activity impacts processes such as growth factor signaling and extracellular matrix organization influencing cell growth and communication. Its role is key in regulating biological pathways through modifying heparan sulfate chains which influences the availability of signaling molecules.

Pathways

NDST2 plays a role in the heparan sulfate biosynthesis and signaling pathways. It interacts with proteins like fibroblast growth factor receptors by modifying heparan sulfate’s structure. This modification is important for the fibrogen and Wnt signaling pathways. Through these pathways NDST2 regulates processes such as development proliferation and tissue repair by facilitating ligand-receptor interactions.

Associated diseases and disorders

NDST2 involvement is observed in conditions like cancer and hereditary multiple exostoses (HME). Aberrant NDST2 function can lead to improper heparan sulfate biosynthesis affecting tumor progression and metastasis in cancer. In HME altered NDST2 activity modifies cartilage growth. Interactions with proteins like EXT1 and EXT2 which are also involved in heparan sulfate biosynthesis highlight NDST2’s relevance in these disorders. Studying NDST2 further may offer insights into therapeutic targets for managing these conditions.