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AB198242

Anti-NDUFA6 antibody

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(1 Publication)

Rabbit Polyclonal NDUFA6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NDUFA6.

View Alternative Names

LYRM6, NADHB14, NDUFA6, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6, Complex I-B14, LYR motif-containing protein 6, NADH-ubiquinone oxidoreductase B14 subunit, CI-B14

1 Images
Western blot - Anti-NDUFA6 antibody (AB198242)
  • WB

Supplier Data

Western blot - Anti-NDUFA6 antibody (AB198242)

10%SDS-PAGE

All lanes:

Western blot - Anti-NDUFA6 antibody (ab198242) at 1/250 dilution

All lanes:

Human kidney tissue lysate at 40 µg

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NDUFA6.

P56556

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NDUFA6 protein also known as NADH:Ubiquinone Oxidoreductase Subunit A6 is an essential component of the mitochondrial respiratory chain complex I. Weighing approximately 15 kDa this protein forms a part of the inner mitochondrial membrane mainly expressed in tissues with high energy demands such as the heart brain and skeletal muscle. The protein aids in the initial steps of electron transfer from NADH to ubiquinone which is an important mechanical function in cellular respiration.
Biological function summary

NDUFA6 participates in the assembly and stability of complex I which is the largest of the five complexes in the mitochondrial electron transport chain. By contributing to complex I NDUFA6 plays a pivotal role in ATP production through oxidative phosphorylation. It ensures the effective transfer of electrons and maintains the proton gradient necessary for ATP synthesis. The integration of NDUFA6 within complex I illustrates its biological necessity for proper cellular energy metabolism.

Pathways

NDUFA6 significantly impacts the oxidative phosphorylation pathway and mitochondrial complex I assembly pathway. Its interaction within these pathways influences the overall energy metabolism and cellular respiration efficiency. The protein engages with several partners including NDUFS2 and NDUFV1 which are also integral subunits of complex I. These interactions highlight how NDUFA6 tightly coordinates with other proteins to ensure optimal energy production.

Defects in NDUFA6 have been associated with mitochondrial diseases such as Leber Hereditary Optic Neuropathy and mitochondrial complex I deficiency. These conditions lead to impaired energy metabolism affecting tissues with high energy demands. In these diseases interactions with proteins like NDUFS1 and other complex I subunits become altered disrupting normal mitochondrial function. Understanding these connections emphasizes the importance of NDUFA6 in maintaining mitochondrial health and cellular energy balance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly (PubMed : 30245030). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
See full target information NDUFA6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 21: PubMed32887414

2020

MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Yokoyama,Yoshitaka Ohno,Tatsuro Egawa,Kazuya Ohashi,Rika Ito,Huascar Pedro Ortuste Quiroga,Tomohiro Yamashita,Katsumasa Goto
View all publications
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Product promise

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