Anti-NDUFB1 Antibody [S04-4H3]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NDUFB1 also known as NADH:ubiquinone oxidoreductase subunit B1 is a component of complex I in the mitochondrial respiratory chain. It plays a role in the transfer of electrons from NADH to ubiquinone. NDUFB1 has a molecular mass of approximately 12.7 kDa. Expression of NDUFB1 is observed in high energy-demanding tissues like the heart brain and skeletal muscles.

Biological function summary

NDUFB1 functions as part of the mitochondrial complex I which is the first enzyme of the electron transport chain. Complex I is essential for energy production in cells as it facilitates the transfer of electrons and contributes to proton gradient formation across the inner mitochondrial membrane. NDUFB1 interacts with other subunits within complex I to ensure efficient electron flow impacting the overall respiratory activity and ATP synthesis.

Pathways

NDUFB1 is involved with the oxidative phosphorylation pathway where it collaborates with other components of complex I like NDUFS7 and NDUFV1. It also associates with the mitochondrial biogenesis pathway important for maintaining mitochondrial function and energy metabolism. Through these pathways NDUFB1 helps to sustain cellular energy balance and integrate mitochondrial signaling processes.

Associated diseases and disorders

Defects in NDUFB1 have been connected to conditions such as mitochondrial complex I deficiency and Leigh syndrome. These diseases result from impaired energy metabolism leading to severe neurological and muscular symptoms. NDUFB1 dysfunction can influence the activity of proteins like NDUFA1 and NDUFS1 amplifying mitochondrial dysfunction and contributing to the progression of these disorders.