Anti-NDUFS2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NDUFS2 also known as NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 is a significant component of complex I in the mitochondrial respiratory chain. This protein has a mass of approximately 54 kDa and is primarily found in mitochondrial membranes of cells across various tissues. It plays an essential role in electron transfer working closely with other subunits to facilitate the conversion of NADH to NAD+ contributing to the process of oxidative phosphorylation.

Biological function summary

NDUFS2 serves an important role in energy production as part of the multi-subunit complex I which is also known as NADH:ubiquinone oxidoreductase. This complex catalyzes the first step in the mitochondrial electron transport chain transferring electrons from NADH to ubiquinone. Through this process NDUFS2 helps power ATP synthesis by contributing to the establishment of a proton gradient across the inner mitochondrial membrane which is fundamental to cellular energy metabolism.

Pathways

The function of NDUFS2 is integral to both the oxidative phosphorylation and citric acid cycle pathways. Within oxidative phosphorylation NDUFS2 associates closely with other complex I subunits such as NDUFS1 and NDUFV1. These associations allow it to effectively participate in the electron transport chain facilitating energy production. The citric acid cycle indirectly impacts NDUFS2's function by supplying NADH which is necessary for complex I activity and efficient energy conversion.

Associated diseases and disorders

NDUFS2 mutations and dysfunctions relate to disorders such as Leigh syndrome and some mitochondrial myopathies. Leigh syndrome a severe neurological disorder often involves deficiencies in complex I where NDUFS2 plays a significant role. This protein also shows connections to other mitochondrial proteins like NDUFA12 and NDUFB6 which when also impaired can contribute to disease manifestations. The study and understanding of NDUFS2's role in these conditions are important for developing potential therapeutic strategies.