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AB105025

Anti-NDUFS7 antibody

3

(1 Review)

|

(2 Publications)

Goat Polyclonal NDUFS7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial aa 50-100.

View Alternative Names

Complex I-20kD, NADH-ubiquinone oxidoreductase 20 kDa subunit, PSST subunit, CI-20kD, NDUFS7

1 Images
Western blot - Anti-NDUFS7 antibody (AB105025)
  • WB

Unknown

Western blot - Anti-NDUFS7 antibody (AB105025)

Primary incubation was 1 hour.

All lanes:

Western blot - Anti-NDUFS7 antibody (ab105025) at 0.1 µg/mL

All lanes:

Human Heart lysate (in RIPA buffer) at 35 µg

Predicted band size: 23 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

O75251

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Goat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab105025 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NDUFS7 also known as NADH:ubiquinone oxidoreductase subunit S7 plays an important role in complex I of the mitochondrial respiratory chain. This protein with a mass of about 21 kDa is expressed in tissues with high energy demands such as heart brain and skeletal muscle. NDUFS7 contributes to the electron transport pathway by facilitating the transfer of electrons from NADH to ubiquinone.
Biological function summary

NDUFS7 becomes a functional component through its participation in the mitochondrial complex I. This large multi-subunit complex is essential for ATP production and consists of 45 subunits. NDUFS7 along with other subunits like NDUFS1 and NDUFS2 ensures the proper assembly and function of this complex. It influences oxidative phosphorylation which is important for cellular energy homeostasis.

Pathways

You will find NDUFS7 incorporated within the oxidative phosphorylation and the tricarboxylic acid (TCA) cycle pathways. NDUFS7 associates closely with other complex I proteins such as NDUFA9 and NDUFB8 impacting the electron transport chain's efficiency. This cooperation supports the ATP synthesis that cells utilize for maintaining metabolic balance.

Mutations in NDUFS7 have associations with mitochondrial diseases like Leigh syndrome and neurodegenerative disorders such as Alzheimer's disease. In Leigh syndrome NDUFS7 alongside other complex I components like NDUFV1 can impair proper mitochondrial functioning leading to severe neurological symptoms. In Alzheimer's disease alterations affecting NDUFS7 might contribute to disrupted energy metabolism suggesting potential therapeutic target opportunities for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed : 17275378). Essential for the catalytic activity of complex I (PubMed : 17275378).
See full target information NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell research 29:579-591 PubMed31133695

2019

AIF-regulated oxidative phosphorylation supports lung cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Shuan Rao,Laura Mondragón,Blanka Pranjic,Toshikatsu Hanada,Gautier Stoll,Thomas Köcher,Peng Zhang,Alexander Jais,Alexander Lercher,Andreas Bergthaler,Daniel Schramek,Katharina Haigh,Valentina Sica,Marion Leduc,Nazanine Modjtahedi,Tsung-Pin Pai,Masahiro Onji,Iris Uribesalgo,Reiko Hanada,Ivona Kozieradzki,Rubina Koglgruber,Shane J Cronin,Zhigang She,Franz Quehenberger,Helmut Popper,Lukas Kenner,Jody J Haigh,Oliver Kepp,Malgorzata Rak,Kaican Cai,Guido Kroemer,Josef M Penninger

Cell metabolism 25:945-953.e6 PubMed28380382

2017

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

Applications

Unspecified application

Species

Unspecified reactive species

Nunziata Maio,Ki Soon Kim,Anamika Singh,Tracey A Rouault
View all publications
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Product promise

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