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AB192517

Anti-NEIL1 antibody

1

(2 Reviews)

|

(1 Publication)

Rabbit Polyclonal NEIL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Endonuclease 8-like 1.

View Alternative Names

Endonuclease 8-like 1, DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, Nei-like protein 1, NEH1, NEIL1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Endonuclease 8-like 1.

Q96FI4

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEIL1 also known as Nei endonuclease VIII-like 1 functions as a DNA glycosylase involved in base excision repair. This protein has a molecular mass of approximately 44 kDa. NEIL1 operates on oxidatively damaged bases in DNA removing lesions from DNA to maintain genome integrity. Expression of NEIL1 occurs in various tissues with higher levels often found in the liver and other metabolically active organs.
Biological function summary

NEIL1 plays an important role in the DNA damage repair process ensuring stability and integrity of the genome. It is particularly active in removing oxidative damage to bases functioning as part of the base excision repair pathway. NEIL1 works in coordination with other proteins such as DNA polymerase and ligase to repair DNA. It does not exist alone but forms complexes with these and other DNA repair proteins to carry out its role efficiently.

Pathways

NEIL1 acts within the base excision repair and nucleotide excision repair pathways. These pathways are vital for correcting DNA damage caused by oxidative stress and other environmental factors. In these pathways NEIL1 interacts with other repair enzymes including DNA polymerase beta to ensure proper coordination during the repair process. The interaction helps streamline the replacement and sealing of damaged DNA segments.

Alterations in NEIL1 function associate with various conditions specifically cancer and neurodegenerative diseases. Mutations or deficiencies in NEIL1 can lead to improper repair of DNA contributing to carcinogenesis. Moreover research indicates NEIL1 may interact with other proteins like p53 a known tumor suppressor linking its role in tumor development and suppression. In neurodegenerative diseases faulty DNA repair mechanisms involving NEIL1 contribute to neuronal damage and disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U : C and T : C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
See full target information Endonuclease 8-like 1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e25227 PubMed38333873

2024

Regulation of PDGFRα cells and ICC in progesterone-mediated slow colon transit in pregnant mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Lu,Hui Luo,Ye Wang,Shuang Jing,Jun Zhao,Kexin Zou,Fan Wu,Hao Ying
View all publications
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