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AB317393

Anti-NEK4 antibody [S09-1I1]

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Rabbit Recombinant Monoclonal NEK4 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human NEK4.

View Alternative Names

STK2, NEK4, Serine/threonine-protein kinase Nek4, Never in mitosis A-related kinase 4, Serine/threonine-protein kinase 2, Serine/threonine-protein kinase NRK2, NimA-related protein kinase 4

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S09-1I1

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NEK4.

P51957

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEK4 also known as NimA-related protein kinase 4 functions as a serine/threonine kinase involved in cell cycle regulation and ciliogenesis. It has a molecular weight of about 84 kDa. NEK4 is expressed widely in various tissues with significant expression in lung skeletal muscle and kidney. Its expression is important for proper cellular processes like mitosis and maintenance of the ciliary structure.
Biological function summary

NEK4 participates in centrosome function and cilia dynamics playing an important role in maintaining cellular integrity. It associates with other proteins in a complex manner to facilitate cell cycle progression. NEK4 shows importance in regulating the stability of microtubules which affects the proper formation and function of cilia.

Pathways

NEK4 integrates into major cellular pathways involved in cell cycle checkpoints and ciliogenesis. It is a part of the cell cycle regulation pathway influencing events necessary for DNA replication and mitotic progression. NEK4 also interacts with proteins like NEK1 which further modulates its activity in regulating cellular responses to DNA damage and ensuring correct cell division.

NEK4 links to conditions such as cancer and primary ciliary dyskinesia. In various cancers NEK4 expression may influence tumor growth and metastasis through its role in cell cycle regulation. In primary ciliary dyskinesia faults in NEK4-related proteins like NEK1 can affect cilia structure and function leading to clinical symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
See full target information NEK4
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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