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AB26812

Anti-Nervous Necrosis Virus antibody

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(4 Publications)

Rabbit Polyclonal Nervous Necrosis Virus antibody. Suitable for WB, ELISA, FuncS (Neut/Block) and reacts with Nervous Necrosis Virus samples. Cited in 4 publications.
1 Images
Western blot - Anti-Nervous Necrosis Virus antibody (AB26812)
  • WB

Supplier Data

Western blot - Anti-Nervous Necrosis Virus antibody (AB26812)

Nervous Necrosis Virus coat protein detected at 40-45kDa by Western Blot analysis.

All lanes : Anti-Nervous Necrosis Virus antibody (ab26812) at 1/5000 dilution

Lane 1 : Negative control

Lane 2 : Barfin flounder Nervous Necrosis Virus capsid protein

Lane 3 : Redspotted grouper Nervous Necrosis Virus capsid protein

Lane 4 : Striped jack Nervous Necrosis Virus capsid protein

All lanes:

Western blot - Anti-Nervous Necrosis Virus antibody (ab26812)

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Nervous Necrosis Virus

Applications

WB, FuncS (Neut/Block), ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

ab26812 recognises Nervous Necrosis Virus.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Nervous Necrosis Virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/10000", "ELISA-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p></p>" } } }
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Product details

This antibody has been shown to be useful in Virus Neutralization studies using virus particles of NNV.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Nervous Necrosis Virus (NNV) also known as the Betanodavirus is a virus that primarily affects fish especially those in aquaculture environments. It has a simple structure with an approximate molecular mass of 43 kDa consisting of a single-stranded RNA genome enclosed within a capsid protein. NNV expresses predominantly in neural tissues and retinal cells of infected fish where it replicates and causes cellular damage.
Biological function summary

The Nervous Necrosis Virus plays a significant role in the pathogenesis of viral nervious necrosis (VNN) by hijacking host cellular mechanisms to replicate and spread within the tissues. It does so with assistance from proteins within its capsid which allow it to attach and enter host cells. There is currently no evidence that NNV forms part of a larger viral complex it usually operates independently.

Pathways

The Nervous Necrosis Virus disrupts normal signaling in fish neurological pathways particularly those linked to neuromuscular functions and vision. NNV interferes with pathways critical for cell survival and division particularly those involving regulatory proteins such as p53 which are responsible for genomic stability. By altering these pathways NNV contributes to cell death and tissue disorganization.

The Nervous Necrosis Virus is associated most prominently with Viral Nervous Necrosis in fish species leading to significant economic losses in aquaculture. This disease manifests through symptoms like erratic swimming color changes and high mortality rates. The virus's interaction with proteins such as p53 and other regulatory factors highlights its potential role in triggering apoptosis in infected cells exacerbating the condition.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Nervous Necrosis Virus
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The veterinary quarterly 40:205-214 PubMed32813983

2020

Role of rotifer () and () nauplii in the horizontal transmission of a natural nervous necrosis virus (NNV) reassortant strain to Senegalese sole () larvae.

Applications

Unspecified application

Species

Unspecified reactive species

L Vázquez-Salgado,J G Olveira,C P Dopazo,I Bandín

Plant methods 15:108 PubMed31548848

2019

Improving plant transient expression through the rational design of synthetic 5' and 3' untranslated regions.

Applications

Unspecified application

Species

Unspecified reactive species

Hadrien Peyret,James K M Brown,George P Lomonossoff

Frontiers in plant science 10:880 PubMed31354759

2019

Plant-Made Nervous Necrosis Virus-Like Particles Protect Fish Against Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Johanna Marsian,Daniel L Hurdiss,Neil A Ranson,Anneli Ritala,Richard Paley,Irene Cano,George P Lomonossoff

Veterinary research 47:6 PubMed26743933

2016

SJNNV down-regulates RGNNV replication in European sea bass by the induction of the type I interferon system.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Carballo,Esther Garcia-Rosado,Juan J Borrego,M Carmen Alonso
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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