Anti-Nervous Necrosis Virus antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Nervous Necrosis Virus (NNV) also known as the Betanodavirus is a virus that primarily affects fish especially those in aquaculture environments. It has a simple structure with an approximate molecular mass of 43 kDa consisting of a single-stranded RNA genome enclosed within a capsid protein. NNV expresses predominantly in neural tissues and retinal cells of infected fish where it replicates and causes cellular damage.

Biological function summary

The Nervous Necrosis Virus plays a significant role in the pathogenesis of viral nervious necrosis (VNN) by hijacking host cellular mechanisms to replicate and spread within the tissues. It does so with assistance from proteins within its capsid which allow it to attach and enter host cells. There is currently no evidence that NNV forms part of a larger viral complex it usually operates independently.

Pathways

The Nervous Necrosis Virus disrupts normal signaling in fish neurological pathways particularly those linked to neuromuscular functions and vision. NNV interferes with pathways critical for cell survival and division particularly those involving regulatory proteins such as p53 which are responsible for genomic stability. By altering these pathways NNV contributes to cell death and tissue disorganization.

Associated diseases and disorders

The Nervous Necrosis Virus is associated most prominently with Viral Nervous Necrosis in fish species leading to significant economic losses in aquaculture. This disease manifests through symptoms like erratic swimming color changes and high mortality rates. The virus's interaction with proteins such as p53 and other regulatory factors highlights its potential role in triggering apoptosis in infected cells exacerbating the condition.