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AB69226

Anti-NETO1 antibody

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(1 Publication)

Mouse Polyclonal NETO1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NETO1.

View Alternative Names

BTCL1, NETO1, Neuropilin and tolloid-like protein 1, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

1 Images
Western blot - Anti-NETO1 antibody (AB69226)
  • WB

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Western blot - Anti-NETO1 antibody (AB69226)

All lanes:

Western blot - Anti-NETO1 antibody (ab69226) at 1/500 dilution

Lane 1:

NETO1 transfected 293T lysate at 25 µg

Lane 2:

Non-transfected 293T lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 60 kDa

Observed band size: 61 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NETO1.

Q8TDF5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NETO1 protein also known as Neuropilin and Tolloid-like 1 is a transmembrane protein with a molecular weight of about 75 kDa. It is primarily expressed in the central nervous system particularly in the hippocampus and cerebellum. NETO1 serves as an auxiliary subunit of ionotropic glutamate receptors specifically the kainate receptor. It modulates the receptor's function by enhancing its kinetics and gating critical for synaptic transmission and plasticity.
Biological function summary

The protein interacts with kainate receptors forming a functional receptor complex that aids in neurotransmission processes. The complex plays a significant role in synaptic scaling and has implications for learning and memory functions. NETO1's ability to bind to various ligands on the glutamate receptor ensures its engagement in critical signal transduction activities across neuronal synapses.

Pathways

The function of NETO1 integrates into neurotransmission and synaptic plasticity pathways. NETO1 plays an important role in the glutamatergic synaptic transmission pathway alongside proteins like the GLUR5 receptor subunit. This involvement facilitates efficient communication between neurons influencing long-term potentiation and depression which are central to learning and memory processes.

NETO1's dysfunction associates with neurological and psychiatric conditions such as schizophrenia and epilepsy. Altered expression or mutations in NETO1 can impact the signaling pathway affecting synaptic strength and neuronal communication. It also interacts with proteins such as DLG4 also known as PSD-95 in these conditions further implicating NETO1 in the stability and function of postsynaptic densities potentially leading to cognitive and behavioral abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
See full target information NETO1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 9:e90952 PubMed24632577

2014

Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ailin Qu,Lutao Du,Yongmei Yang,Hui Liu,Juan Li,Lili Wang,Yimin Liu,Zhaogang Dong,Xin Zhang,Xiumei Jiang,Haiyan Wang,Zewu Li,Guixi Zheng,Chuanxin Wang
View all publications
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