Anti-Netrin 4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Netrin 4 also known as NTN4 or Netrin-G2 is a secreted protein in the netrin family with a molecular mass of approximately 70 kDa. This protein exhibits a characteristic laminin-like domain which is responsible for its interactions with cellular receptors. Netrin 4 is expressed mainly in basement membranes of many tissue types including neuronal tissues the vascular system and the epithelial lining. The expression patterns suggest roles in distinct physiological processes and developmental stages linked to tissue organization.

Biological function summary

Netrin 4 interacts with the extracellular matrix and contributes to tissue morphogenesis and stability. It does not function in isolation but forms part of a complex network of signaling proteins. Through its binding to specific receptors like UNC5B and neogenin Netrin 4 signals pathways that impact cell adhesion migration and survival. The diverse biological roles position Netrin 4 as an important mediator involved in orchestrating cellular behavior and tissue patterning.

Pathways

Scientists have identified the involvement of Netrin 4 in signaling pathways such as the axon guidance and angiogenesis pathways. The protein acts alongside related proteins like Netrin-1 leveraging the netrin family’s role in guiding axonal development and blood vessel formation. These pathways suggest Netrin 4's capacity to influence neurodevelopmental and vascular processes mediated by its interaction with other guidance cues and ligands.

Associated diseases and disorders

Research links Netrin 4 with conditions such as cancer and cardiovascular disorders. In cancer abnormal expression or signaling can influence tumor progression due to its role in cell migration and angiogenesis with proteins like UNC5B involved in this dysregulation. In cardiovascular disease altered Netrin 4 levels can affect vascular integrity and remodeling activities. These associations indicate potential therapeutic implications as modulating Netrin 4 pathways might offer novel avenues for disease intervention.