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AB254986

Anti-Netrin G2 antibody

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(1 Publication)

Rabbit Polyclonal Netrin G2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NTNG2 aa 50-150.

View Alternative Names

KIAA1857, LMNT2, UNQ9381/PRO34206, NTNG2, Netrin-G2, Laminet-2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Netrin G2 antibody (AB254986)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Netrin G2 antibody (AB254986)

Paraffin-embedded human lymph node tissue stained for Netrin G2 using ab254986 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NTNG2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q96CW9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Netrin G2 also known as Netrin-G2 or NTNG2 is a protein that weighs approximately 61 kDa. Netrin G2 belongs to the Netrin family and operates through binding with its receptors. It is expressed mainly in the central nervous system particularly in the brain regions like cortex and hippocampus. The protein facilitates communication across nerve cells by directing axon guidance and maintaining synaptic plasticity.
Biological function summary

This protein plays an essential role in neuronal development and synaptic connections. Netrin G2 acts as a part of cell surface signaling modules allowing interaction with other molecular entities. It binds to Netrin G2 ligands which helps stabilize long-range axonal trajectories. Due to this function Netrin G2 contributes to maintaining proper neural circuit assembly necessary for cognitive functions.

Pathways

Netrin G2 plays a part in the axon guidance and synaptogenesis pathways. It interacts with other guidance cues proteins such as DCC (Deleted in Colorectal Cancer) and UNC5B (Unc-5 Netrin Receptor B) which also participate in the regulation of axonal mapping. Throughout these pathways it ensures neurons reach their correct destination therefore influencing neural map precision and adaptability.

Mutations or dysregulation of Netrin G2 have associations with neurological conditions like schizophrenia and autism spectrum disorders. Alterations in Netrin G2 might affect its interaction with related proteins like DCC in these conditions. These disruptions can contribute to improper brain function by interfering with typical pathways of axonal targeting and synaptic stability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
See full target information NTNG2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:5342 PubMed40533478

2025

Reversible proliferative arrest induced by rapid depletion of RNase MRP.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Liu,Shiyang He,Kawon Pyo,Reuben Franklin,Ibrahim B Maaz,Chen Cai,Kriti Shah,Sihem Cheloufi,William F Marzluff,Jernej Murn
View all publications
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Product promise

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