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AB133732

Anti-Netrin G2 antibody [EPR4570(2)]

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(1 Publication)

Rabbit Recombinant Monoclonal Netrin G2 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA1857, LMNT2, UNQ9381/PRO34206, NTNG2, Netrin-G2, Laminet-2

3 Images
Flow Cytometry - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)
  • Flow Cyt

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Flow Cytometry - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)

Flow cytometry analysis of Jurkat cells staining Netrin G2, using ab133732 at 1/100 dilution (red) or a control Rabbit IgG (green).

Western blot - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)
  • WB

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Western blot - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)

All lanes:

Western blot - Anti-Netrin G2 antibody [EPR4570(2)] (ab133732) at 1/1000 dilution

Lane 1:

Fetal brain tissue lysate at 10 µg

Lane 2:

Jurkat cell lysate at 10 µg

Secondary

All lanes:

HRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Predicted band size: 60 kDa

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OI-RD Scanning - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)
  • OI-RD Scanning

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OI-RD Scanning - Anti-Netrin G2 antibody [EPR4570(2)] (AB133732)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

  • Carrier free

    Anti-Netrin G2 antibody [EPR4570(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4570(2)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/100 - 1/500", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Netrin G2 also known as Netrin-G2 or NTNG2 is a protein that weighs approximately 61 kDa. Netrin G2 belongs to the Netrin family and operates through binding with its receptors. It is expressed mainly in the central nervous system particularly in the brain regions like cortex and hippocampus. The protein facilitates communication across nerve cells by directing axon guidance and maintaining synaptic plasticity.
Biological function summary

This protein plays an essential role in neuronal development and synaptic connections. Netrin G2 acts as a part of cell surface signaling modules allowing interaction with other molecular entities. It binds to Netrin G2 ligands which helps stabilize long-range axonal trajectories. Due to this function Netrin G2 contributes to maintaining proper neural circuit assembly necessary for cognitive functions.

Pathways

Netrin G2 plays a part in the axon guidance and synaptogenesis pathways. It interacts with other guidance cues proteins such as DCC (Deleted in Colorectal Cancer) and UNC5B (Unc-5 Netrin Receptor B) which also participate in the regulation of axonal mapping. Throughout these pathways it ensures neurons reach their correct destination therefore influencing neural map precision and adaptability.

Mutations or dysregulation of Netrin G2 have associations with neurological conditions like schizophrenia and autism spectrum disorders. Alterations in Netrin G2 might affect its interaction with related proteins like DCC in these conditions. These disruptions can contribute to improper brain function by interfering with typical pathways of axonal targeting and synaptic stability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
See full target information NTNG2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:794 PubMed34093750

2021

Effects of extract on lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Huixiang Tian,Yueqin Li,Jie Mei,Lei Cao,Jiye Yin,Zhaoqian Liu,Juan Chen,Xiangping Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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