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AB222806

Anti-Neurexin I beta antibody

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(2 Publications)

Rabbit Polyclonal NRX1B antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NRXN1.

View Alternative Names

Neurexin-1-beta, Neurexin I-beta, NRXN1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Neurexin I beta antibody (AB222806)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Neurexin I beta antibody (AB222806)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for Neurexin I beta (green) using ab222806 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-Neurexin I beta antibody (AB222806)
  • WB

Supplier Data

Western blot - Anti-Neurexin I beta antibody (AB222806)

All lanes:

Western blot - Anti-Neurexin I beta antibody (ab222806) at 1/2000 dilution

Lane 1:

Mouse heart lysate

Lane 2:

Mouse kidney lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 161 kDa

Observed band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NRXN1.

P58400

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  • 2
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Secondary Antibodies

AB150077

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  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurexin I beta also known as Neurexin-1 is a synaptic cell adhesion molecule that plays a significant role in the nervous system. This protein is part of the neurexin family and spans the cell membrane linking neurons together. It typically weighs around 61 kDa. Neurexin I beta is expressed widely in the brain particularly in the synaptic regions. It facilitates the communication between presynaptic and postsynaptic neurons important for neurotransmitter release.
Biological function summary

Neurexin I beta participates in synaptic vesicle fusion and supports synapse formation. It forms part of a complex interacting system with neuroligins and LRRTMs maintaining synaptic stability and organization. Neurexin I beta's role in synapse assembly and function suggests its importance in neurodevelopmental processes. Its interaction with neuroligins indicates its involvement in synaptic specification.

Pathways

Neurexin I beta is engaged in synaptic adhesion and neurotransmitter release pathways. It associates with neuroligins and synaptotagmin maintaining synaptic structure and function. The neurotransmitter release pathway includes calcium ion entry triggering synaptic vesicle fusion. The interactions between Neurexin I beta and these proteins ensure efficient synaptic signaling and plasticity essential for cognitive functions.

Altered Neurexin I beta function has been linked to neurodevelopmental disorders particularly autism spectrum disorders and schizophrenia. Its association with neuroligins plays a role in these conditions due to the disrupted synaptic connectivity and communication. In autism spectrum disorders mutations in Neurexin I beta and neuroligins have been observed suggesting their involvement in synaptic dysfunctions. In schizophrenia synaptic plasticity disruptions connect Neurexin I beta's altered pathways to the disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (By similarity). Plays a role in formation of synaptic junctions (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (By similarity).
See full target information NRXN1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell research 33:30-45 PubMed36241718

2022

A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Rongjie Cheng,Fanying Li,Maolei Zhang,Xin Xia,Jianzhuang Wu,Xinya Gao,Huangkai Zhou,Zhi Zhang,Nunu Huang,Xuesong Yang,Yaliang Zhang,Shunli Shen,Tiebang Kang,Zexian Liu,Feizhe Xiao,Hongwei Yao,Jianbo Xu,Chao Yan,Nu Zhang

Neural plasticity 2020:8815195 PubMed32802036

2020

Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health.

Applications

Unspecified application

Species

Unspecified reactive species

Sen Yin,Xuemei Bai,Danqing Xin,Tingting Li,Xili Chu,Hongfei Ke,Min Han,Wenqiang Chen,Xingang Li,Zhen Wang
View all publications
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Product promise

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