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AB64186

Anti-Neuritin antibody

3

(1 Review)

|

(8 Publications)

Rabbit Polyclonal Neuritin antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human NRN1.

View Alternative Names

NRN, NRN1, Neuritin

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuritin antibody (AB64186)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuritin antibody (AB64186)

ab64186 (10ug/ml) staining Neuritin in human brain, cortex tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Western blot - Anti-Neuritin antibody (AB64186)
  • WB

Unknown

Western blot - Anti-Neuritin antibody (AB64186)

Western blot analysis of neuritin in Daudi cell lysate using ab64186 at (A) 5 and (B) 10 µg/ml.

All lanes:

Western blot - Anti-Neuritin antibody (ab64186)

Predicted band size: 15 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human NRN1. The exact immunogen used to generate this antibody is proprietary information.

Q9NPD7

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Complementary Products

Proteins & Peptides

AB69755

Recombinant human Neuritin protein

Bioactive

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB16640

Anti-Sortilin/NT3 antibody

KO Validated

Western blot - Anti-Sortilin/NT3 antibody (AB16640)

  • 5
  • 10
Primary Antibodies

AB7800

Anti-Cytokeratin 14 antibody [LL002]

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 14 antibody [LL002] (AB7800)

  • 5
  • 27
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuritin sometimes called cpg15 is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular mass of about 15 kDa. It is mainly expressed in the central nervous system particularly in areas involved with learning and memory including the hippocampus and the cerebral cortex. Neuritin plays a role in the development and plasticity of neurons assisting in processes like neurite outgrowth which supports neural connectivity and regeneration.
Biological function summary

Neuritin influences neuronal development by promoting neurite extension and synaptic remodeling. It has not been identified as part of a larger complex but interacts with cell surface molecules to exert its effects. Neuritin supports synapse formation and stabilization which are important for effective synaptic transmission and plasticity in neurons. This function gives neuritin a significant role in the regulation of neural circuits that underlie learning and cognitive functions.

Pathways

Neuritin plays roles in the neural growth and plasticity pathways. It has been associated with the MAPK/ERK signaling pathway influencing synaptic function and structure. Neuritin also interacts with small GTPases which are involved in axonal growth and dendritic branching. These interactions with other proteins help to mediate its effects on neuron structure and function contributing to overall neural network adaptability.

Neuritin has links to neurological conditions such as Alzheimer's disease and major depressive disorder. Its expression levels change in response to these diseases suggesting a protective or compensatory role. Neuritin interacts with amyloid precursor protein (APP) in Alzheimer's disease possibly influencing amyloid-beta production and plaque formation. In major depressive disorder interactions with brain-derived neurotrophic factor (BDNF) may affect mood regulation and synaptic health reflecting neuritin's potential impact on disease progression and symptomatology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
See full target information NRN1
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry and biophysics reports 42:102044 PubMed40476059

2025

Recombinant human Neuritin protects cochlear ribbon synapses and hearing function via ERK1/2 activation post noise-induced injury.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyan Wang,Jinchi Hu,Shuangyan Liu,Fei Gui,Xiaopin Sun,Rong Chen,Guanwu Yin,Xiaoming Song,Yi Yang,Yu Hong

International journal of molecular sciences 26: PubMed40332354

2025

Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Wang,Shaowei Lv,Junhao Hu,Yunfan Shi,Yu Li,Jianyun Zhang,Xiaohua Tan,Rong Chen,Yu Hong

Brain research 1845:149293 PubMed39454807

2024

Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Kunhao Ren,Linzhi Dai,Hao Zhang,Yaowen He,Bin Liu,Youjie Hu,Ketao Ma,Weidong Tian,Dong Zhao

Molecular & cellular proteomics : MCP 22:100542 PubMed37024090

2023

Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Cheyenne Hurst,Derian A Pugh,Measho H Abreha,Duc M Duong,Eric B Dammer,David A Bennett,Jeremy H Herskowitz,Nicholas T Seyfried

Acta biochimica et biophysica Sinica 53:663-672 PubMed33787845

2021

Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Li Yang,Xuhui Wang,Jiawei Sun,Chunyan Liu,Guoxiang Li,Jingling Zhu,Jin Huang

International journal of molecular medicine 46:384-396 PubMed32626916

2020

miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.

Applications

Unspecified application

Species

Unspecified reactive species

Dandan Song,Guoxiang Li,Yu Hong,Pan Zhang,Jingling Zhu,Lei Yang,Jin Huang

International journal of molecular sciences 20: PubMed31491902

2019

Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Endah Rahmawati,Wei-Chung Vivian Yang,Yen-Ping Lei,Pawan Kumar Maurya,Huei-Wen Chen,Chii-Ruey Tzeng

Oncology letters 10:1197-1203 PubMed26622652

2015

microRNA-182 inhibits the proliferation and migration of glioma cells through the induction of neuritin expression.

Applications

Unspecified application

Species

Unspecified reactive species

Y A Feng,T E Liu,Yuncheng Wu
View all publications
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Product promise

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