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AB272650

Anti-neurobeachin-like 1 antibody

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Rabbit Polyclonal neurobeachin-like 1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NBEAL1 aa 2500-2650.

View Alternative Names

ALS2CR16, ALS2CR17, NBEAL1, Neurobeachin-like protein 1, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-neurobeachin-like 1 antibody (AB272650)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-neurobeachin-like 1 antibody (AB272650)

Paraffin-embedded formalin-fixed human kidney tissue stained for neurobeachin-like 1 using ab272650 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-neurobeachin-like 1 antibody (AB272650)
  • WB

Unknown

Western blot - Anti-neurobeachin-like 1 antibody (AB272650)

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Western blot - Anti-neurobeachin-like 1 antibody (ab272650)

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Western blot - Anti-neurobeachin-like 1 antibody (ab272650) at 0.4 µg/mL

Lane 1:

Molecular Weight ladder

Lane 2:

RT4 cells (Human urinary bladder cancer cell line)

Lane 3:

U-251 MG cells (Human brain glioma cell line)

Lane 4:

Human plasma (IgG/HSA depleted)

Lane 5:

Human liver tissue

Lane 6:

Human tonsil tissue

Predicted band size: 151 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human NBEAL1 aa 2500-2650. The exact immunogen used to generate this antibody is proprietary information.

Q6ZS30

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurobeachin-like 1 (NBEAL1) is a protein involved in several cellular activities. Also known as KIAA1566 it has a molecular mass of approximately 327 kDa. NBEAL1 is expressed in a variety of human tissues including brain and testes. It contains several domains such as the BEACH coiled-coil and WD40 domains which are important for its intracellular functions. Through these domains NBEAL1 mechanistically engages in protein-protein interactions and possibly influences vesicular trafficking and signal transduction within the cell.
Biological function summary

NBEAL1 helps in the regulation of synaptic activity and neuronal growth. It functions within larger protein complexes that are involved in the synaptic vesicle cycle influencing neurotransmitter release and synaptic plasticity. The BEACH domain in NBEAL1 is critical for its involvement in endosomal and lysosomal trafficking. This function can modulate cellular homeostasis impacting various neuronal processes essential for interpreting external and internal signals.

Pathways

Several cellular pathways involve the roles of NBEAL1 notably in neuronal function. It is an essential participant in synaptic vesicle endocytosis and recycling. In this context it interacts with proteins like CALM and AP2 which are integral to the formation and reconnection of synaptic vesicles within nerve terminals. This association places NBEAL1 within the larger framework of neurotransmission and maintenance of synaptic integrity.

Alterations in NBEAL1 function relate to neurological conditions such as autism spectrum disorders and neurodegenerative diseases. Studies suggest that NBEAL1 interaction with proteins like TSC1 and TSC2 may contribute to these conditions possibly through disrupted cellular signaling and synaptic abnormalities. Understanding NBEAL1 interactions opens avenues for exploring therapeutic potential in neurodevelopmental and neurodegenerative disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information NBEAL1
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Product promise

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