Anti-Neurogenin3/NGN-3 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Neurogenin3 plays a significant role in the differentiation of endocrine cells within the pancreas. Neurogenin3 functions by binding to specific DNA sequences initiating the transcription of genes necessary for endocrine cell maturation. It does not operate as part of a large complex but acts by recruiting other co-factors to modulate the gene expression directly. Through its transcriptional activity neurogenin3 initiates a cascade of events leading to the differentiation of pancreatic progenitor cells into distinct endocrine lineages such as insulin-producing beta cells.

Pathways

Neurogenin3 integrates into dynamic signaling networks that guide the differentiation process of pancreatic progenitor cells. Notably neurogenin3 is a vital component of the Notch signaling pathway which it helps regulate by activating and repressing genes that determine cell fate. Neurogenin3 interacts with other important proteins such as HES1 and PAX4 within these pathways. The tight balance between these factors and neurogenin3 expression levels determines the progression of progenitor cells into specific cell types.