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AB197670

Anti-Neuroglobin antibody

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(1 Publication)

Rabbit Polyclonal Neuroglobin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Neuroglobin.

View Alternative Names

Neuroglobin, Nitrite reductase, NGB

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuroglobin antibody (AB197670)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuroglobin antibody (AB197670)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Neuroglobin with ab197670 at 1/20 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Neuroglobin.

Q9NPG2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuroglobin often referred to as Ngb is a globin protein with a molecular mass of approximately 17 kDa. It is present mainly in the nervous system including the brain and retina. Ngb functions mechanically by binding oxygen and other gaseous molecules. Unlike other globins it has a hexacoordinate heme and switches between different redox states. This property allows Ngb to participate in molecular signaling and oxygen homeostasis. Neuroglobin's expression occurs in neurons glial cells and some peripheral tissues suggesting a specialized yet wide-ranging role in cellular environments.
Biological function summary

Neuroglobin supports cellular survival under hypoxic or oxidative stress conditions. It is not part of a larger complex but interacts independently with cellular components. Ngb can protect neural cells from apoptosis by interfering with mitochondrial pathways and caspase activation. It acts as a scavenger for reactive oxygen species reducing cellular damage. Its protective nature against neuronal injury gives it significance in maintaining cellular homeostasis and responding to metabolic stress.

Pathways

Neuroglobin is associated with oxygen delivery and neuroprotection processes. It participates in hypoxia signaling pathways and neuroprotective pathways aiding in cell defense mechanisms. Neuroglobin's role intersects with signaling proteins such as hypoxia-inducible factor (HIF-1) contributing to the regulation of oxygen-dependent gene expression. Additionally Ngb engages with various cellular pathways to mitigate oxidative damage though its connections are typically direct rather than collaborative with other proteins.

Neuroglobin connects with Alzheimer's disease and ischemic stroke both linked to oxidative stress and neuronal damage. Researchers have observed Ngb's influence in limiting neuronal apoptosis and preserving cognitive function suggesting a protective role in Alzheimer's disease. In ischemic stroke models elevated Ngb expression appears to reduce brain injury by enhancing tissue resilience under low-oxygen conditions. Additionally Ngb interactions with amyloid-beta a protein associated with Alzheimer's disease highlight its potential role in neurodegenerative research and therapy development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed : 11473128, PubMed : 12962627, PubMed : 24699645). Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it (PubMed : 11473128, PubMed : 12860983, PubMed : 12962627, PubMed : 24699645). The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia (PubMed : 21296891). In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress (PubMed : 12860983, PubMed : 18302932).
See full target information Neuroglobin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 10: PubMed33672843

2021

Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study.

Applications

Unspecified application

Species

Unspecified reactive species

Renate Pichler,Andrea Katharina Lindner,Georg Schäfer,Gennadi Tulchiner,Nina Staudacher,Martin Mayr,Eva Comperat,Jacob J Orme,Gert Schachtner,Martin Thurnher
View all publications
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Product promise

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