Goat Polyclonal Neurogranin antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human NRGN aa 1 to C-terminus.
View Alternative Names
Neurogranin, Ng, RC3, NRGN
- IHC-P
Lab
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurogranin antibody (AB99269)
ab99269 (3.8µg/ml) staining of paraffin embedded Human Cortex shows cytoplasm staining in the neuronal cell bodies. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
- WB
Unknown
Western blot - Anti-Neurogranin antibody (AB99269)
Primary incubation was 1 hour.
All lanes:
Western blot - Anti-Neurogranin antibody (ab99269) at 0.1 µg/mL
All lanes:
Mouse brain lysate in RIPA buffer at 35 µg
Predicted band size: 8 kDa
true
- WB
Unknown
Western blot - Anti-Neurogranin antibody (AB99269)
All lanes:
Western blot - Anti-Neurogranin antibody (ab99269) at 2 µg/mL
Lane 1:
Human cerebellum lysates at 35 µg
Lane 2:
Rat brain lysates at 35 µg
Predicted band size: 8 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Neurogranin functions as a modulator in cerebellar signaling and synaptic transmission. It influences calcium-calmodulin signaling facilitating the activation of proteins important in the central nervous system. Neurogranin does not form part of a multi-protein complex but interacts closely with calmodulin to regulate downstream signal cascades. These interactions emphasize its fundamental role in modulating processes that influence cognitive functions like learning and memory.
Pathways
Neurogranin significantly impacts the calcium signaling pathway and contributes to the regulation of long-term potentiation. It closely associates with proteins such as Protein Kinase C (PKC) and calmodulin-dependent protein kinases which are instrumental in these pathways. By modulating these essential signaling routes neurogranin affects intracellular signals that are vital for synaptic plasticity and enhanced neural communication.
Product protocols
- Visit the General protocols
- Visit the Troubleshooting
Target data
Publications (3)
Recent publications for all applications. Explore the full list and refine your search
Journal of biochemical and molecular toxicology 38:e23711 PubMed38605443
2024
Applications
Unspecified application
Species
Unspecified reactive species
eLife 11: PubMed36226913
2022
Applications
Unspecified application
Species
Unspecified reactive species
Brain, behavior, and immunity 82:178-187 PubMed31437533
2019
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com