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AB153821

Anti-Neuroligin 1 antibody

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(4 Publications)

Rabbit Polyclonal Neuroligin 1 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NLGN1 aa 100-300.

View Alternative Names

KIAA1070, NLGN1, Neuroligin-1

1 Images
Western blot - Anti-Neuroligin 1 antibody (AB153821)
  • WB

Unknown

Western blot - Anti-Neuroligin 1 antibody (AB153821)

7.5% SDS PAGE

All lanes:

Western blot - Anti-Neuroligin 1 antibody (ab153821) at 1/1000 dilution

All lanes:

U87-MG whole cell lysate at 30 µg

Predicted band size: 94 kDa,96 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human NLGN1 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q8N2Q7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuroligin 1 also known as NLGN1 is a member of the neuroligin family of cell adhesion molecules. It plays a significant mechanical role at synaptic junctions where it mediates synapse formation and maintenance. Neuroligin 1 weighs approximately 97 kDa and is mainly expressed in the brain particularly in postsynaptic densities of excitatory glutamatergic synapses. Neuroligin 1 interacts with neurexins on the presynaptic side facilitating trans-synaptic connections important for proper neuronal communication.
Biological function summary

Neuroligin 1 contributes to synaptic organization and signaling by being part of a larger protein complex. This complex involves postsynaptic scaffolding proteins such as PSD-95 which anchor neuroligin to the cytoskeleton and receptors like NMDA and AMPA receptors. Neuroligin 1 regulates synaptic stabilization and plasticity which are essential for learning and memory processes. Through these interactions it impacts synaptic strength and efficiency playing an integral role in the modulation of synaptic activity.

Pathways

Neuroligin 1 is a critical component of synaptic development and function pathways. It operates within the synaptic signaling and plasticity pathways affecting neurotransmitter function and reception. Neuroligin 1 functions in coordination with proteins such as neurexins and SHANK proteins to regulate the assembly and maturation of synapses. These interactions influence calcium signaling and involve the recruitment of other synaptic proteins that further contribute to synaptic modulation.

Neuroligin 1 is linked to neurological conditions like autism spectrum disorders (ASD) and schizophrenia. Mutations or dysregulations of neuroligin 1 impact synaptic connectivity leading to altered neuronal networks and communication deficits involved in these conditions. The balance of excitatory and inhibitory synaptic function that neuroligin and its binding partners including neurexins and SHANK3 control is directly implicated in the pathophysiology of these disorders. Disruptions in neuroligin-neurexin signaling pathways may therefore contribute to the synaptic dysfunctions observed in ASD and schizophrenia.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development.
See full target information NLGN1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 24:896-905 PubMed35681009

2022

Mechanical force application to the nucleus regulates nucleocytoplasmic transport.

Applications

Unspecified application

Species

Unspecified reactive species

Ion Andreu,Ignasi Granero-Moya,Nimesh R Chahare,Kessem Clein,Marc Molina-Jordán,Amy E M Beedle,Alberto Elosegui-Artola,Juan F Abenza,Leone Rossetti,Xavier Trepat,Barak Raveh,Pere Roca-Cusachs

Contrast media & molecular imaging 2022:6177809 PubMed35711530

2022

Regulation of the Proliferation of Diabetic Vascular Endothelial Cells by Degrading Endothelial Cell Functional Genes with QKI-7.

Applications

Unspecified application

Species

Unspecified reactive species

Jinmei Xu,Qingsong Zhao,Xu Han,Zheqi Zhang,Jiahui Qu,Zhifeng Cheng

Nature communications 11:3812 PubMed32732889

2020

Targeting QKI-7 in vivo restores endothelial cell function in diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Chunbo Yang,Magdalini Eleftheriadou,Sophia Kelaini,Thomas Morrison,Marta Vilà González,Rachel Caines,Nicola Edwards,Andrew Yacoub,Kevin Edgar,Arya Moez,Aleksandar Ivetic,Anna Zampetaki,Lingfang Zeng,Fiona L Wilkinson,Noemi Lois,Alan W Stitt,David J Grieve,Andriana Margariti

Nature communications 11:3594 PubMed32681011

2020

CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiyu Xu,Ying Zhang,Wandi Xiong,Zhongyu Zhang,Zhengbo Wang,Longbao Lv,Chao Liu,Zhengfei Hu,Yong-Tang Zheng,Lin Lu,Xin-Tian Hu,Jiali Li
View all publications
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