Rabbit Polyclonal Neuroligin 2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLGN2.
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Publications
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- Frontiers in molecular neuroscience 15:8311512022The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Wen,Yaowei Xu,Zhixiang Yu,Yifan Zhou,Wenting Wang,Jingjie Yang,Yiming Wang,Qian Bai,Zhisong LiPubMed 35401106
- The EMBO journal 37:427-4452018Mapping protein interactions of sodium channel Na1.7 using epitope-tagged gene-targeted mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandros H Kanellopoulos et. al.PubMed 29335280
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
Lyophilized
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human NLGN2. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFZ4
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).
Alternative names
KIAA1366, NLGN2, Neuroligin-2
Recommended products
Rabbit Polyclonal Neuroligin 2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLGN2.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
Lyophilized
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human NLGN2. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFZ4
- Purification technique
Affinity purification Immunogen
- Reconstitution
Reconstitute in 200ul sterile H2O.
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Neuroligin 2 also known as NLGN2 is a postsynaptic cell adhesion molecule with a mass of approximately 106 kDa. It plays an important role in forming and maintaining synaptic connections which are essential for communication between neurons. Neuroligin 2 is predominately expressed in the central nervous system and can be found at inhibitory synapses where it interacts with other synaptic proteins to maintain synaptic structure and function.
- Biological function summary
This synaptic adhesion protein plays a part in the formation of synapses and the modulation of synaptic strength. Neuroligin 2 forms a trans-synaptic complex with neurexins on the presynaptic side which helps to stabilize synapses by mediating cell-cell interactions. This interaction is important for maintaining balance between excitatory and inhibitory signals in the brain which contributes to normal brain function and neuronal communication.
- Pathways
Neuroligin 2 functions as an integral part of synaptic signaling and neural network activity. It is connected to synaptic pathways that govern synapse assembly which involves other proteins like PSD-95. In particular its interaction with neurexins plays a role in the formation of the inhibitory synapses pathway which regulates inhibitory neurotransmission. Through these pathways Neuroligin 2 influences how neurons communicate and process information within neural circuits.
- Associated diseases and disorders
This protein associates with certain neurological and psychiatric conditions. Altered Neuroligin 2 function has links to autism spectrum disorders and schizophrenia. In these diseases its interaction with proteins such as neurexin may be disrupted which can impact synaptic balance and lead to deficits in synaptic function. Studying Neuroligin 2 helps to understand these disorders better and potentially develop therapeutic strategies targeting synaptic adhesion molecules.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Neuroligin 2 antibody (ab177107)
All lanes: Western blot - Anti-Neuroligin 2 antibody (ab177107) at 1/500 dilution
All lanes: HeLa lysate
Predicted band size: 91 kDa
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