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AB181353

Anti-Neuronatin antibody [EPR13554(B)]

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(1 Publication)

Rabbit Recombinant Monoclonal Neuronatin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Neuronatin, NNAT

1 Images
Western blot - Anti-Neuronatin antibody [EPR13554(B)] (AB181353)
  • WB

Supplier Data

Western blot - Anti-Neuronatin antibody [EPR13554(B)] (AB181353)

All lanes:

Western blot - Anti-Neuronatin antibody [EPR13554(B)] (ab181353) at 1/10000 dilution

Lane 1:

Fetal brain lysate at 10 µg

Lane 2:

SH-SY5Y cell lysate at 10 µg

Predicted band size: 9 kDa

false

  • Carrier free

    Anti-Neuronatin antibody [EPR13554(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13554(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuronatin also known as Nnat is a protein involved in neural development. It exists as a polypeptide with a molecular weight of approximately 8 kDa. Neuronatin is expressed mainly in the brain’s central nervous system particularly in developing neurons. It plays a role in the differentiation and maturation of neural cells. Researchers also identify neuronatin in tissues such as the pituitary gland and the pancreas.
Biological function summary

Neuronatin influences the development and functioning of the nervous system. It does not form part of a complex but associates with lipid membranes. By interacting with calcium ions neuronatin participates in calcium signaling important for neuronal growth. Neuronatin also has a regulatory function in apoptosis the programmed cell death thereby affecting the overall cell population and neuronal health.

Pathways

Neuronatin plays a role in calcium ion homeostasis and neural signaling pathways. It affects the calcium signaling pathway which is essential for neural differentiation and plasticity. The protein calbindin which buffers intracellular calcium interacts with neuronatin in these pathways. Neuronatin also relates to the neurotrophin signaling pathway where it can influence neuron survival and growth.

Certain alterations in neuronatin expression link to neurological conditions such as Alzheimer's disease and epilepsy. In Alzheimer's neuronatin's interaction with amyloid precursor protein can influence the progression of the disease. Concerning epilepsy changes in calcium signaling involving neuronatin may contribute to the disorder's pathophysiology potentially connecting neuronatin with other proteins like calmodulin involved in calcium regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.
See full target information Neuronatin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular neuroscience 12:35 PubMed30814928

2019

Down-Regulation of miRNA-708 Promotes Aberrant Calcium Signaling by Targeting Neuronatin in a Mouse Model of Angelman Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Naman Vatsa,Vipendra Kumar,Brijesh Kumar Singh,Shashi Shekhar Kumar,Ankit Sharma,Nihar Ranjan Jana
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com